Evidence map›Paper›PMID 42047693›Full record

ArticleArchives of toxicology2026

Functionalised thin multi-walled carbon nanotubes are less toxic to lung cells in vitro than their native counterparts.

Carole Seidel, Sylvie Sébillaud, Christian Darne, Brigitte Vigolo, Mélanie Emo, Marlène Mascherin, Frédéric Cosnier, Laurent Gaté

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In one paragraph

Article in Archives of toxicology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Carole SeidelDépartement Toxicologie et Biométrologie, Institut National de Recherche et de Sécurité pour la prévention des accidents du travail et des maladies professionnelles (INRS), 1 rue du Morvan, 54519, Vandoeuvre-lès- Nancy, France. carole.seidel@inrs.fr.ORCID 0009-0004-8211-6839
Sylvie SébillaudDépartement Toxicologie et Biométrologie, Institut National de Recherche et de Sécurité pour la prévention des accidents du travail et des maladies professionnelles (INRS), 1 rue du Morvan, 54519, Vandoeuvre-lès- Nancy, France.
Christian DarneDépartement Toxicologie et Biométrologie, Institut National de Recherche et de Sécurité pour la prévention des accidents du travail et des maladies professionnelles (INRS), 1 rue du Morvan, 54519, Vandoeuvre-lès- Nancy, France.
Brigitte VigoloUniversité de Lorraine, CNRS, IJL, F-54000, Nancy, France.
Mélanie EmoUniversité de Lorraine, CNRS, IJL, F-54000, Nancy, France.
Marlène MascherinDépartement Toxicologie et Biométrologie, Institut National de Recherche et de Sécurité pour la prévention des accidents du travail et des maladies professionnelles (INRS), 1 rue du Morvan, 54519, Vandoeuvre-lès- Nancy, France.
Frédéric CosnierDépartement Toxicologie et Biométrologie, Institut National de Recherche et de Sécurité pour la prévention des accidents du travail et des maladies professionnelles (INRS), 1 rue du Morvan, 54519, Vandoeuvre-lès- Nancy, France.
Laurent GatéDépartement Toxicologie et Biométrologie, Institut National de Recherche et de Sécurité pour la prévention des accidents du travail et des maladies professionnelles (INRS), 1 rue du Morvan, 54519, Vandoeuvre-lès- Nancy, France.

Funding

Institut national de la recherche et de sécurité Institut national de la recherche et de sécurité
6 · The paper itself

Abstract

Functionalisation of carbon nanotubes (CNTs), to make them more hydrophilic, is an essential step in their preparation for use in a wide range of industrial processes. The toxicological impact of these modifications has been investigated. However, due to the diversity of experimental models used in studies, no consensus has yet been reached. Here, we studied the toxicity of multi-walled CNT (MWCNT) with or without hydroxyl or carboxyl functional groups in lung cell models-chosen due to the risk of inhalation exposure for employees during handling of nanomaterials. In this study, we investigated the induction of the epithelial-mesenchymal transition (EMT) of human bronchial epithelial cells BEAS-2B following 6 weeks of treatment with MWCNTs ranging from 0.125 to 1 µg/cm

Indexed as

Epithelial CellsEpithelial-Mesenchymal TransitionLungNanotubes, CarbonA549 CellsAnimalsCell LineCell SurvivalHumansInterleukin-8Macrophages, AlveolarRatsInterleukin-8Nanotubes, CarbonBinucleated macrophagesEpithelial-mesenchymal transitionFunctionalisationIL-8 expressionLung toxicityMulti-walled carbon nanotubes

Identifiers

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.