ReviewJournal of Parkinson's disease2026
Parkinson's disease and the concept of resilience, cognitive, and motor reserve.
Review in Journal of Parkinson's disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
1 author.
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Abstract
Parkinson's disease (PD) shows pronounced clinical heterogeneity, with individuals presenting differing cognitive and motor trajectories despite similar levels of neurodegeneration, in particular striatal dopamine terminal loss. This variability underscores the relevance of considering resilience mechanisms, particularly cognitive and motor reserve, that may support preserved function in the face of progressive pathology and neurodegeneration. Building on a previously proposed conceptual framework of resilience in PD, this review provides an updated and integrative synthesis of recent evidence, including longitudinal studies, neuroimaging findings, and emerging insights into lifestyle-related factors. The review further extends the existing framework by addressing current methodological challenges and outlining future directions for incorporating resilience into neuroimaging research, biological staging models, and personalized intervention strategies in PD. Together, this work emphasizes the growing importance of resilience research in PD and its potential to improve prognostic accuracy and inform more precise and individualized therapeutic approaches.
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