ArticleGenetics and molecular biology2026
Conserved gene clusters in entomopathogenic filamentous fungi.
Article in Genetics and molecular biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Entomopathogenic filamentous fungi from the Order Hypocreales are studied for biological pest control due to their ability to infect arthropods. Their biotechnological potential lies in the production of secondary metabolites (SMs), encoded by biosynthetic gene clusters (BGCs), which are crucial for the fungal life cycle and infection. Due to the different roles played by SMs in fungi, the in-depth study of these molecules has increased over the last years. Considering the proven biotechnological importance of species of the genus Beauveria have already shown, we performed an in-silico analysis of BGCs of the species from the order Hypocreales to uncover potential conserved pathways and find new candidates for biological pest control. A total of 295 genome sequences were analyzed using antiSMASH, allowing the identification of 12,968 BGCs. Conservation analysis was performed using BiG-SCAPE, which could group these BGCs into 2,127 biosynthetic gene families. Despite the presence of conserved gene clusters, especially within the same genus, when the comparison of BGCs was performed within the order, a large part of them is orphaned, highlighting the great diversity of BGCs and consequently the chemodiversity of fungal species. Our approach helps to uncover new molecules that may provide new biotechnological tools.
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