ArticleInternational journal of urology : official journal of the Japanese Urological Association2026
Gleason Regrading After Prostatectomy-Results From the Irish Prostate Cancer Outcome Research (IPCOR) Situated in the International Context.
Article in International journal of urology : official journal of the Japanese Urological Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
backgroundAccurate Gleason grading is crucial for prostate cancer (PCa) treatment decisions; incorrect assessment can lead to under- or overtreatment; discordance between biopsy and radical prostatectomy (RP) grades is a marker of this inaccuracy. Using the Irish Prostate Cancer Outcomes Research (IPCOR) cohort, we sought to quantify Gleason grade concordance, upgrading, and downgrading trends in PCa RP patients, assess the impact of pre-biopsy MRI on diagnostic accuracy, and compare Irish trends with international findings.
methodsA contextual literature review summarized international regrading rates. IPCOR enrolled 6816 men diagnosed with PCa. We included 1194 men who underwent both biopsy and RP within 180 days. Biopsy and RP Gleason Grade Groups (GG) were compared to estimate concordance, upgrading, and downgrading. Sub-analyses examined regrading by biopsy modality and pre-biopsy MRI.
resultsOverall concordance was 57.0%, similar international median of 52.9%. Concordance was lowest for GG1 (32.7%) and highest for GG2 (74.8%), while higher GGs showed frequent downgrading (GG4 46.8%; GG5 33.3%). Among men with TRUS biopsy, pre-biopsy MRI was associated with higher concordance (59.8% vs. 55.8%) and lower upgrading (19.3% vs. 29.4%), though differences were not statistically significant.
conclusionsGleason regrading patterns in Ireland mirror global experience, with upgrading in lower and downgrading in higher GGs. Pre-biopsy MRI shows a favorable trend toward improved diagnostic accuracy, supporting its integration into clinical pathways.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.