Evidence map›Paper›PMID 42047351›Full record

ArticleACS infectious diseases2026

Role of Ambler Position 104 in Defining Substrate Specificity in the KPC Family of β-Lactamases.

Lin Gao, Steven Marshall, Christopher R Bethel, Andrea M Hujer, Magdalena A Taracila, Kristine M Hujer, Shozeb Haider, Robert A Bonomo

Abstract read
In one paragraph

Article in ACS infectious diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Lin GaoUCL School of Pharmacy, LondonWC1N 1AX, U.K.
Steven MarshallResearch Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio44106-1702, United States.
Christopher R BethelResearch Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio44106-1702, United States.
Andrea M HujerDepartment of Medicine, Division of Infectious Diseases, Case Western Reserve University School of Medicine, Cleveland, Ohio44106-1702, United States.ORCID 0009-0001-3543-1826
Magdalena A TaracilaResearch Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio44106-1702, United States.
Kristine M HujerDepartment of Medicine, Division of Infectious Diseases, Case Western Reserve University School of Medicine, Cleveland, Ohio44106-1702, United States.
Shozeb HaiderUCL School of Pharmacy, LondonWC1N 1AX, U.K.ORCID 0000-0003-2650-2925
Robert A BonomoResearch Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio44106-1702, United States.ORCID 0000-0002-3299-894X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Carbapenem-resistant Gram-negative bacteria pose a critical clinical challenge, largely due to the dissemination of class A

Indexed as

Bacterial Proteinsbeta-LactamasesKlebsiella pneumoniaeAmino Acid SubstitutionAnti-Bacterial AgentsAzabicyclo Compoundsbeta-Lactamase Inhibitorsbeta-LactamsCatalytic DomainCefiderocolCeftazidimeEscherichia coliKineticsMicrobial Sensitivity TestsMolecular Dynamics SimulationSubstrate SpecificityAnti-Bacterial AgentsAzabicyclo CompoundsBacterial Proteinsbeta-Lactamase Inhibitorsbeta-Lactamasesbeta-LactamsCefiderocolCeftazidimecarbapenemasecefiderocol resistanceceftazidime avibactam resistanceKPCP104KP104R

Identifiers

PMID42047351
PMCPMC13162249

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.