Evidence map›Paper›PMID 42047346›Full record

ArticleEuropean journal of clinical investigation2026

Identification of miR-150-5p in Human Amniotic Membrane Mesenchymal Cell-Derived Extracellular Vesicles as a Novel Mechanism Driving Cardioprotection.

Nunzio Alcharani, Laura Tesoro, Javier Díez-Mata, José Luis Zamorano, Marta Saura, Maite Iglesias, Carlos Zaragoza

Abstract read
In one paragraph

Article in European journal of clinical investigation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Nunzio AlcharaniUnidad Mixta de Investigación Cardiovascular Universidad Francisco de Vitoria, Hospital Ramon y Cajal (IRYCIS), Madrid, Spain.
Laura TesoroUnidad Mixta de Investigación Cardiovascular Universidad Francisco de Vitoria, Hospital Ramon y Cajal (IRYCIS), Madrid, Spain.
Javier Díez-MataUnidad Mixta de Investigación Cardiovascular Universidad Francisco de Vitoria, Hospital Ramon y Cajal (IRYCIS), Madrid, Spain.
José Luis ZamoranoDepartamento de Cardiología, Hospital Universitario Ramón y Cajal (IRYCIS), Madrid, Spain.
Marta SauraCentro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Instituto de Salud Carlos III (ISCIII), Madrid, Spain.
Maite IglesiasFacultad de Ciencias Experimentales, Universidad Francisco de Vitoria, Madrid, Spain.
Carlos ZaragozaUnidad Mixta de Investigación Cardiovascular Universidad Francisco de Vitoria, Hospital Ramon y Cajal (IRYCIS), Madrid, Spain.

Funding

Universidad Francisco de Vitoria UFV 2023
6 · The paper itself

Abstract

backgroundHuman amniotic membrane mesenchymal stem cells (hAMSCs) hold strong cardioprotective potential, yet their mechanisms of action remain largely elusive. METHODS AND

resultsC57BL/6 mice were subjected to cardiac ischemia/reperfusion (I/R) and received intravenous (IV) 2 × 10

conclusionshAMSCs promote cardioprotection following I/R via the MIAT/miR-150-5p/HOXA4 axis, in which miR-150-5p plays a central role. These findings provide loss-of-function evidence about the therapeutic potential of hAMSC-derived EVs as a novel cell-free exosome-based strategy for the treatment of acute myocardial infarction.

Indexed as

AmnionExtracellular VesiclesMesenchymal Stem CellsMesenchymal Stem Cell TransplantationMicroRNAsMyocardial InfarctionMyocardial Reperfusion InjuryAnimalsHomeodomain ProteinsHumansMaleMiceMice, Inbred C57BLMyocardiumHomeodomain ProteinsMicroRNAsMIR150, humanMirn150 microRNA, mouseacute myocardial infarctioncardioprotectionextracellular vesiclesHOXA4human amniotic mesenchymal stem cellsischemia/reperfusionMIATmiR‐150‐5p

Identifiers

PMID42047346
PMCPMC13123203

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.