Evidence map›Paper›PMID 42047327›Full record

ArticleBioMed research international2026

Phytochemical Analysis, In Vitro and In Vivo Evaluation of Ficus altissima Extract-Based Ointment and Hydrogel on Wound Healing.

Hossein M Elbadawy, Aryam S Alharbi, Ahmed K B Aljohani, Asalah B Alhazmi, Manhal N Hudhayri, Salma A Ibrahim, Israa B Almuwalld, Maya A Alhazmi, Shuruq M Almohammadi, Ahmed Aldhafiri and 5 more

Abstract read
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In one paragraph

Article in BioMed research international, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Hossein M ElbadawyDepartment of Pharmacology and Toxicology, College of Pharmacy, Taibah University, Madinah, Saudi Arabia, taibahu.edu.sa.ORCID https://orcid.org/0000-0001-8675-0838
Aryam S AlharbiCollege of Pharmacy, Taibah University, Medina, Saudi Arabia, taibahu.edu.sa.
Ahmed K B AljohaniHealth and Life Research Center, Taibah University, Madinah, Saudi Arabia, taibahu.edu.sa.ORCID https://orcid.org/0000-0003-2332-1125
Asalah B AlhazmiCollege of Pharmacy, Taibah University, Medina, Saudi Arabia, taibahu.edu.sa.
Manhal N HudhayriCollege of Pharmacy, Taibah University, Medina, Saudi Arabia, taibahu.edu.sa.
Salma A IbrahimDepartment of Pharmacognosy, Faculty of Pharmacy, Galala University, Suez, Egypt, gu.edu.eg.
Israa B AlmuwalldCollege of Pharmacy, Taibah University, Medina, Saudi Arabia, taibahu.edu.sa.
Maya A AlhazmiCollege of Pharmacy, Taibah University, Medina, Saudi Arabia, taibahu.edu.sa.
Shuruq M AlmohammadiCollege of Pharmacy, Taibah University, Medina, Saudi Arabia, taibahu.edu.sa.
Ahmed AldhafiriDepartment of Pharmacology and Toxicology, College of Pharmacy, Taibah University, Madinah, Saudi Arabia, taibahu.edu.sa.
Heba M EltahirDepartment of Pharmacology and Toxicology, College of Pharmacy, Taibah University, Madinah, Saudi Arabia, taibahu.edu.sa.
Mekky M AbouziedDepartment of Pharmacology and Toxicology, College of Pharmacy, Taibah University, Madinah, Saudi Arabia, taibahu.edu.sa.
Hamad AlrbyawiDepartment of Pharmaceutics and Pharmaceutical Industries, College of Pharmacy, Taibah University, Madinah, Saudi Arabia, taibahu.edu.sa.
Mohamed R KamelDepartment of Pharmacognosy, Faculty of Pharmacy, Al-Azhar University, Assiut, Egypt, azhar.edu.eg.
Fahd M AbdelkaremDepartment of Pharmacognosy, Faculty of Pharmacy, Al-Azhar University, Assiut, Egypt, azhar.edu.eg.ORCID https://orcid.org/0000-0002-6388-0821

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveWound healing is a sequential mechanism that occurs in four successive stages: hemostasis, inflammation, proliferation, and remodeling. Delayed wound healing and the subsequent complications can be observed in poorly controlled chronic diseases and immunocompromised patients. This study focused on the wound-healing activity of Ficus altissima extract-based formulations, exploring their phytochemical and biological properties.

methodsPhytochemical characterization was conducted using HPLC, GC-MS, and spectroscopic methods for quantification of phenolic compounds and flavonoids. Disk diffusion was utilized to test the antimicrobial effects of the extract, and antioxidant activity was measured using DPPH assay. Anti-inflammatory activity was assessed by the quantification of NF-κB and TNF-α levels in LPS-stimulated RAW 264.7 cells. An ointment and hydrogel were prepared from F. altissima aerial parts and tested for their wound-healing effect using skin wound-healing model in rats.

resultsPhenolic acids, flavonoid compounds, fatty acids, and sugar derivatives were detected in F. altissima extract with total phenolic and total flavonoid contents equal to 144.81 mg·GAE g

conclusionsF. altissima extract, particularly in an ointment form, effectively promoted wound healing and tissue regeneration, and this effect can be linked to the detected phenolic acids and flavonoids with anti-inflammatory, antioxidant, and antimicrobial properties.

Indexed as

FicusHydrogelsPhytochemicalsPlant ExtractsWound HealingAnimalsAnti-Inflammatory AgentsAntioxidantsFlavonoidsMaleMiceNF-kappa BOintmentsRatsRAW 264.7 CellsTumor Necrosis Factor-alphaAnti-Inflammatory AgentsAntioxidantsFlavonoidsHydrogelsNF-kappa BOintmentsPhytochemicalsPlant ExtractsTumor Necrosis Factor-alphaanti-inflammatoryFicus altissimaointment-based formulationphytochemical characterizationwound healing

Identifiers

PMID42047327
PMCPMC13122729

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.