Evidence map›Paper›PMID 42047209›Full record

ArticleAmerican journal of epidemiology2026

Negatives about positivity and consistency as conditions for causal inference.

Sander Greenland, Stephen R Cole

Abstract read
In one paragraph

Article in American journal of epidemiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Sander GreenlandDepartment of Epidemiology and Department of Statistics, University of California, Los Angeles, CA, United States.ORCID 0000-0003-4364-3279
Stephen R ColeDepartment of Epidemiology Gillings School of Public Health, University of North Carolina, Chapel Hill, NC, United States.ORCID 0000-0003-2117-1311

Funding

Improved analysis of experiments and observational studies in HIVR01AI157758 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Stephen R Cole, Jessie Edwards · 2020 to 2026
$5.0M
NIAID NIH HHS R01 AI157758NIAID NIH HHS R01AI157758
6 · The paper itself

Abstract

Positivity and causal consistency are sometimes presented as general validity requirements. Positivity, however, is not a general requirement for causal inference and does not address the more demanding practical needs for adequate numbers of observations. Common statistical methods in health and medical research depend on large-sample approximations; yet, approximation accuracy is rarely discussed in research reports, even in cases where it has clearly failed. Prioritization by generality and practical importance shifts the emphasis to approximation accuracy over positivity, with the latter better cast as a technical requirement for specific types of methods. Meanwhile, consistency mixes requirements for operationally clear definitions of treatments with more general needs for accurate measurement. All statistical methods depend on conceptual precision and measurement accuracy; hence, those conditions belong among fundamental requirements for valid inferences, alongside control of selection bias and confounding. When measurement problems are addressed in the basic assumptions of formalizations, consistency can be seen as a definition of the targeted outcome variable in a causal model, rather than a central assumption that mixes separate concerns about construct ambiguity and coarsening.

Indexed as

CausalityModels, StatisticalBiasConfounding Factors, EpidemiologicData Interpretation, StatisticalHumansReproducibility of Resultsbiascausalitycoarseningconsistencyerrormeasurementpositivityvalidity

Identifiers

PMID42047209
PMCPMC13537848

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.