Evidence map›Paper›PMID 42047177›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Temporal Interference Stimulation Enhances Neural Regeneration.

Sofia Peressotti, Maria Garcia Garrido, Patrycja Dzialecka, Rachel Man Hoi Law, Roberto Portillo-Lara, Bethany Geary, Elena Faillace, Shirine Merlo-Nikpay Aslie, Marcelina Wojewska, Maria Otero-Jimenez and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Temporal Interference Stimulation Enhances Neural Regeneration.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Sofia PeressottiBioengineering Department, Imperial College London, South Kensington, London, UK.ORCID https://orcid.org/0000-0003-3474-6807
Maria Garcia GarridoDepartment of Brain Sciences, Imperial College London, Hammersmith Hospital, London, UK.ORCID https://orcid.org/0000-0002-2656-6382
Patrycja DzialeckaDepartment of Brain Sciences, Imperial College London, Hammersmith Hospital, London, UK.ORCID https://orcid.org/0009-0005-0081-4682
Rachel Man Hoi LawPsychiatry and Fundamental Neuroscience Department, University of Geneva, Geneva, Switzerland.ORCID https://orcid.org/0009-0000-7779-7079
Roberto Portillo-LaraBioengineering Department, Imperial College London, South Kensington, London, UK.ORCID https://orcid.org/0000-0002-1781-3126
Bethany GearyUK Dementia Research Institute, London, UK.ORCID https://orcid.org/0000-0002-5592-5532
Elena FaillaceBioengineering Department, Imperial College London, South Kensington, London, UK.ORCID https://orcid.org/0009-0001-9939-7508
Shirine Merlo-Nikpay AslieBioengineering Department, Imperial College London, South Kensington, London, UK.ORCID https://orcid.org/0009-0007-9235-3418
Marcelina WojewskaDepartment of Brain Sciences, Imperial College London, Hammersmith Hospital, London, UK.
Maria Otero-JimenezDepartment of Brain Sciences, Imperial College London, Hammersmith Hospital, London, UK.ORCID https://orcid.org/0009-0008-0714-8696
Martina GentaBioengineering Department, Imperial College London, South Kensington, London, UK.ORCID https://orcid.org/0000-0003-3873-2840
Luqiao TanDepartment of Brain Sciences, Imperial College London, Hammersmith Hospital, London, UK.
Karen DuffUK Dementia Research Institute, London, UK.ORCID https://orcid.org/0000-0002-6177-868X
Javier Alegre-AbarrateguiDepartment of Brain Sciences, Imperial College London, Hammersmith Hospital, London, UK.ORCID https://orcid.org/0000-0002-5958-7753
Rylie GreenBioengineering Department, Imperial College London, South Kensington, London, UK.ORCID https://orcid.org/0000-0003-1569-7288
Nir GrossmannDepartment of Brain Sciences, Imperial College London, Hammersmith Hospital, London, UK.ORCID https://orcid.org/0000-0003-2002-9049

Funding

Engineering and Physical Sciences Research Council UKEP/W004844/1European Research Council 771985Imperial Biomedical Research CentreNational Institute for Health and Care ResearchUK Dementia Research Institute
6 · The paper itself

Abstract

Neural regeneration therapies aim to treat neurodegeneration by promoting the proliferation and maturation of exogenous or endogenous neural progenitor cells (NPCs). However, their efficacy has been limited. Deep brain stimulation (DBS) via implanted electrodes has been shown to promote neurogenesis in vitro and in vivo. Still, its invasiveness precludes deployment in research and widespread clinical use. Temporal interference (TI) has emerged as a strategy for non-invasive, high-precision DBS using multiple kHz-range electric fields to target the deep brain. Here, we validate the potential of TI stimulation for neural regeneration augmentation in the central nervous system (CNS). First, we showed that TI stimulation modulated at the theta-band frequency enhances the maturation of embryonic neural progenitor cells in vitro. We then demonstrate that theta-band TI stimulation targeting the hippocampus enhances endogenous hippocampal neurogenesis in an in vivo mouse model of Alzheimer's disease-like amyloidosis. By uncovering frequency-specific control of stem cell fate, we propose a clinically relevant regeneration strategy that avoids pharmacological or genetic manipulation. Our results enable focal, non-invasive augmentation of deep-brain neural regeneration via electrical stimulation.

Indexed as

Alzheimer DiseaseDeep Brain StimulationHippocampusNerve RegenerationNeural Stem CellsNeurogenesisAnimalsDisease Models, AnimalMiceadult neurogenesisalzheimer's diseaseneural progenitor cellsneural regenerationneuromodulationtemporal interference stimulation

Identifiers

PMID42047177
PMCPMC13334665

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.