ArticleClinical cardiology2026
Apolipoprotein A-I (CSL112) and Cardiovascular Outcomes in Atherosclerotic Cardiovascular Disease: A Scoping Review.
Article in Clinical cardiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Pathological depositions in human disease: converging mechanisms in atherosclerosis, Alzheimer's disease, and related disorders.Molecular biomedicine · 2026Review
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundApolipoprotein A-I (ApoA-I), the principal protein component of high-density lipoproteins (HDL), plays a pivotal role in cardiovascular physiology and has gained increasing attention in atherosclerotic cardiovascular disease (ASCVD). Its involvement extends beyond lipid transport to include anti-inflammatory and antioxidant mechanisms.
objectiveTo comprehensively evaluate the role of ApoA-I in ASCVD, including its biological functions, clinical relevance as a biomarker, and potential as a therapeutic target.
methodsA scoping review of the literature was conducted to examine current evidence on ApoA-I in cardiovascular health and disease. Studies assessing its role in reverse cholesterol transport (RCT), association with cardiovascular outcomes, and emerging therapeutic strategies were included.
resultsApoA-I contributes significantly to reverse cholesterol transport and exhibits antioxidant and anti-inflammatory properties that protect against atherosclerosis. Elevated ApoA-I levels are consistently associated with reduced risk of major adverse cardiovascular events, supporting its utility as a biomarker for cardiovascular risk assessment. However, variability in HDL particle composition and the influence of confounding factors such as comorbidities and lifestyle limit its interpretability. Therapeutic approaches targeting ApoA-I, including infusion therapies and mimetic peptides, have shown mixed results in clinical trials, highlighting ongoing challenges.
conclusionApoA-I remains a promising biomarker and therapeutic target in ASCVD, though its clinical application is complicated by biological and methodological variability. Future research focusing on gene therapies, small molecule modulators, and ApoA-I mimetics may enhance its functional properties and clinical utility. Integrating ApoA-I into personalized treatment strategies could improve cardiovascular outcomes and reduce disease burden.
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