Evidence map›Paper›PMID 42046924›Full record

Trial reportOphthalmic epidemiology2026

Baseline Predictors for the Postoperative Trachomatous Trichiasis Following Lid Rotation Surgery in the FLuorometholone as Adjunctive MEdical Therapy for Trachomatous Trichiasis Surgery (FLAME) Trial.

Ha-Neul Yu, Fangming Jin, Aida Abashawl, Ahlam Awad Mohammed, Sarity Dodson, Wondu Alemayehu, Alemu Gemechu, Aemero Abateneh Mengesha, Dereje Adugna Kumsa, Vatinee Y Bunya and 6 more

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Ophthalmic epidemiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Ha-Neul YuThe Perelman School of Medicine, The University of Pennsylvania, Philadelphia, PA, USA.
Fangming JinScheie Eye Institute/Department of Ophthalmology, the Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Aida AbashawlBerhan Public Health and Eye Care Consultancy, Addis Ababa, Ethiopia.
Ahlam Awad MohammedBerhan Public Health and Eye Care Consultancy, Addis Ababa, Ethiopia.
Sarity DodsonThe Fred Hollows Foundation, Addis Ababa, Ethiopia and Melbourne, Australia.
Wondu AlemayehuThe Fred Hollows Foundation, Addis Ababa, Ethiopia and Melbourne, Australia.
Alemu GemechuThe Fred Hollows Foundation, Addis Ababa, Ethiopia and Melbourne, Australia.
Aemero Abateneh MengeshaBerhan Public Health and Eye Care Consultancy, Addis Ababa, Ethiopia.
Dereje Adugna KumsaOromia Regional Health Bureau, Addis Ababa, Ethiopia.
Vatinee Y BunyaScheie Eye Institute/Department of Ophthalmology, the Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Maureen G MaguireScheie Eye Institute/Department of Ophthalmology, the Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Matthew J BurtonInternational Center for Eye Health, London School of Hygiene & Tropical Medicine, London, UK.
John H KempenDepartment of Ophthalmology and Schepens, Eye Research Institute, Massachusetts Eye and Ear Infirmary Institution, Boston, MA, USA.
Gui-Shuang YingScheie Eye Institute/Department of Ophthalmology, the Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0002-5752-1355
All Authors agree to be accountable for all aspects of the work
FLuorometholone as Adjunctive MEdical Therapy for Trachomatous Trichiasis Surgery (FLAME) Trial Research Group

Funding

Fluorometholone as Adjunctive Therapy for Trachomatous Trichiasis SurgeryUG1EY030420 · NEI · MASSACHUSETTS EYE AND EAR INFIRMARY · PI KEMPEN, JOHN H · 2019 to 2023
$4.2M
Fluoromethelone as Adjunctive Medical Therapy for TT Surgery (FLAME) TrialUG1EY030419 · NEI · UNIVERSITY OF PENNSYLVANIA · PI YING, GUI-SHUANG · 2019 to 2023
$2.4M
NEI NIH HHS UG1 EY030419NEI NIH HHS UG1 EY030420
6 · The paper itself

Abstract

purposeTo evaluate predictive factors for postoperative trachomatoustrichiasis (PTT) following trachomatous trichiasis (TT) surgery in an atrachoma-endemic setting.

methodsSecondary analysis of the FLuorometholone as Adjunctive MEdicaltherapy for TT surgery (FLAME) trial for comparing fluorometholone 0.1% vs placebo as adjunctive therapy for TT surgery. A total of 3,218 upper eyelids from 2398 participants underwent posteriorlamellar (PLTR) or bilamellar (BLTR) tarsal rotation surgery and were assessed for PTT at week 4 and at months 6 and 12 post-surgery. PTT wasdefined as ≥1 lashes touching the globe, evidence of epilation, and/or repeat TT surgery. Baseline demographic and ocular characteristics were assessed for predicting 12-month PTT incidenceusing logistic regression, accounting for inter-eye correlation with generalized estimating equations.

resultsBy 12 months, 431 upper eyelids (13.4%) developed PTT. Increasing age (adjusted odds ratio (aOR) = 1.93 for 60+ vs ≤29 years,

conclusionsSeveral baseline demographic and ocular characteristics indicating TT severity are predictive of PTT. Using these findings to identify high-risk individuals can inform clinical decision-making/patientcounselling.

Indexed as

EyelidsFluorometholoneGlucocorticoidsOphthalmologic Surgical ProceduresPostoperative ComplicationsTrachomaTrichiasisAdultAgedDouble-Blind MethodFemaleHumansIncidenceMaleMiddle AgedRisk FactorsFluorometholoneGlucocorticoidsFluorometholone as Adjunctive MEdical therapy for TT surgery (FLAME) trialpostoperative trachomatous trichiasispredictorsPTTtrachoma

Identifiers

PMID42046924
PMCPMC13280629

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.