Evidence map›Paper›PMID 42046874›Full record

ReviewJournal of Zhejiang University. Science. B2026

Sporadic Alzheimer's disease with bipolar-like features: a case report and a brief review of the current research status.

Lingzhuo Kong, Yan Yang, Weihua Zhou, Shaohua Hu

Abstract readReviewCase Reports
In one paragraph

Review in Journal of Zhejiang University. Science. B, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Lingzhuo KongDepartment of Psychiatry, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.
Yan YangDepartment of Psychiatry, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.
Weihua ZhouDepartment of Psychiatry, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.
Shaohua HuDepartment of Psychiatry, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China. dorhushaohua@zju.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alzheimer's disease (AD) is among the main causes of cognitive impairment, memory loss, and dementia, particularly in old adults. It has been listed as one of the most expensive, lethal, and burdening diseases of the 21st century and develops with the process of aging worldwide (Scheltens et al., 2021). Currently, it is widely acknowledged that the typical pathogenesis of AD involves the deposition of amyloid-β (Aβ) and Tau proteins in the cerebral parenchyma and vasculature, intraneuronal neurofibrillary tangles, and the gradual degeneration of synapses (Scheltens et al., 2016; Rostagno, 2022). According to several hypotheses, abnormalities and dysfunctions in vascular structure, mitochondrial metabolism, oxidative stress, glucose utilization, and neuroinflammation are considered fundamental for AD pathology (Scheltens et al., 2016).

Indexed as

Alzheimer DiseaseBipolar DisorderAmyloid beta-PeptidesFemaleHumansOxidative Stresstau ProteinsAmyloid beta-Peptidestau Proteins

Identifiers

PMID42046874
PMCPMC13121885

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.