Evidence map›Paper›PMID 42046870›Full record

ArticleJournal of Zhejiang University. Science. B2026

TAF1 aggravates ferroptosis by promoting the ubiquitin-mediated degradation of nuclear GPX4.

Kehong Ye, Meifu Gan, Liang Sun, Chaoyi Chen, Xuan Lai, Yinjun He, Ming Zhu, Weiqin Jiang, Honghe Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of Zhejiang University. Science. B, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kehong YeDepartment of Pathology, Zhejiang University School of Medicine, Hangzhou 310058, China.
Meifu GanTaizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Taizhou 317000, China.
Liang SunDepartment of Pathology, Zhejiang University School of Medicine, Hangzhou 310058, China.
Chaoyi ChenDepartment of Colorectal Surgery and Oncology (Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education, Key Laboratory of Molecular Biology in Medical Sciences, Zhejiang Province, China), The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China.
Xuan LaiDepartment of Pathology, Zhejiang University School of Medicine, Hangzhou 310058, China.
Yinjun HeDepartment of Pathology, State Key Laboratory of Complex Severe and Rare Disease, Molecular Pathology Research Center, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.
Ming ZhuDepartment of Pathology, Zhejiang University School of Medicine, Hangzhou 310058, China.
Weiqin JiangDepartment of Colorectal Surgery and Oncology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310006, China. weiqinjiang@zju.edu.cn.
Honghe ZhangDepartment of Pathology, Zhejiang University School of Medicine, Hangzhou 310058, China. honghezhang@zju.edu.cn.

Funding

the Chinese Academy of Medical Sciences (CAMS) Innovation Fund for Medical Sciences 2019-I2M-5-044the National Natural Science Foundation of China 82473008, 82173223 and 82303644the Zhejiang Medical and Health Science and Technology Project 2025KY439
6 · The paper itself

Abstract

Glutathione peroxidase 4 (GPX4) is a primary inhibitor of ferroptosis, a regulated form of cell death driven by the accumulation of lipid hydroperoxides. GPX4 exists in three isoforms localized in the cytosol, mitochondria, and nucleus; however, the regulatory mechanisms governing nuclear GPX4 (nGPX4) remain largely unclear. Herein, we identified TATA box-binding protein-associated factor 1 (TAF1) as a pivotal regulator of nGPX4. TAF1 phosphorylates nGPX4, leading to its lysine 11 (K11)-linked ubiquitination and proteasomal degradation, thereby promoting ferroptosis in tumor protein p53 (

Indexed as

FerroptosisPhospholipid Hydroperoxide Glutathione PeroxidaseTATA-Binding Protein Associated FactorsTranscription Factor TFIIDUbiquitinAnimalsCell NucleusHistone AcetyltransferasesHumansMiceProteolysisTumor Suppressor Protein p53UbiquitinationHistone AcetyltransferasesPhospholipid Hydroperoxide Glutathione PeroxidaseTATA-binding protein associated factor 250 kDaTATA-Binding Protein Associated FactorsTranscription Factor TFIIDTumor Suppressor Protein p53UbiquitinFerroptosisGlutathione peroxidase 4 (GPX4)Protein degradationTATA box-binding protein-associated factor 1 (TAF1)Tumor protein p53 (TP53)

Identifiers

PMID42046870
PMCPMC13121887

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.