Trial reportClinical and experimental dental research2026
Modified Cryotherapy During Final Irrigation Reduces Postoperative Pain and Anxiety in Pediatric Primary Molar Root Canal Therapy.
Trial report in Clinical and experimental dental research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed.
- Modified Cryotherapy During Final Irrigation Reduces Postoperative Pain and Anxiety in Pediatric Primary Molar Root Canal Therapy.Clinical and experimental dental research · 2026Trial
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Authors and funding
7 authors.
Funding
Abstract
objectivesPostoperative pain and dental anxiety are significant barriers to effective pediatric endodontic treatment. Improving patient comfort and cooperation remains a critical clinical objective in school-age children undergoing primary molar root canal therapy (RCTP). Conventional pharmacologic strategies have limitations in acceptability, safety, and efficacy, prompting the exploration of non-invasive alternatives. The aim of this study is to evaluate the effect of modified cryotherapy using 0°C saline as the final irrigation protocol on postoperative pain levels and anxiety control in school-age children undergoing RCTP. MATERIAL AND
methodsThis single-center, randomized, controlled clinical trial enrolled 104 school-age patients diagnosed with pulp or periapical disease in deciduous molars. Patients were randomly allocated to either a modified cryotherapy group or a control group. Pain levels were assessed using the Wong-Baker FACES Pain Rating Scale (WB Scale) at baseline, 6, 24, 48 h, and 7 days postoperatively. Anxiety and cooperation were evaluated at baseline and 7-day follow-up using the Venham Scale. Statistical analyses included Chi-square and Mann-Whitney U tests, with significance at p < 0.05.
resultsBaseline characteristics were comparable between groups. The cryotherapy group showed significantly lower pain scores at 6 h,24 h, and 48 h (p < 0.001) post-treatment compared to controls. At 7 days, pain levels converged with no significant difference. The cryotherapy group also demonstrated significantly improved anxiety scores (p = 0.005) and clinical cooperation (p = 0.012) at follow-up compared to the control group.
conclusionModified cryotherapy applied during final root canal irrigation significantly reduces short-term postoperative pain and enhances clinical cooperation in school-age children.
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