Evidence map›Paper›PMID 42046856›Full record

ArticleJournal of the American Chemical Society2026

Unlocking Selenium Chemical Space via a Programmable Synthesis Platform Bearing Cannabinoid Receptor Recognition Motifs.

Malliga R Iyer, Pinaki Bhattacharjee, Subhradeep Dutta, Maloba M M Lobe, Paul D Volesky, Grzegorz Godlewski, Henry L Puhl, Sergio A Hassan

Abstract read
In one paragraph

Article in Journal of the American Chemical Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Malliga R IyerSection on Medicinal Chemistry, National Institute on Alcohol Abuse and Alcoholism (NIAAA), National Institutes of Health (NIH), 5625 Fishers Lane, Rockville, Maryland 20852, United States.ORCID 0000-0002-0116-4619
Pinaki BhattacharjeeSection on Medicinal Chemistry, National Institute on Alcohol Abuse and Alcoholism (NIAAA), National Institutes of Health (NIH), 5625 Fishers Lane, Rockville, Maryland 20852, United States.ORCID 0000-0003-1818-3610
Subhradeep DuttaSection on Medicinal Chemistry, National Institute on Alcohol Abuse and Alcoholism (NIAAA), National Institutes of Health (NIH), 5625 Fishers Lane, Rockville, Maryland 20852, United States.
Maloba M M LobeSection on Medicinal Chemistry, National Institute on Alcohol Abuse and Alcoholism (NIAAA), National Institutes of Health (NIH), 5625 Fishers Lane, Rockville, Maryland 20852, United States.
Paul D VoleskySection on Medicinal Chemistry, National Institute on Alcohol Abuse and Alcoholism (NIAAA), National Institutes of Health (NIH), 5625 Fishers Lane, Rockville, Maryland 20852, United States.
Grzegorz GodlewskiLaboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism (NIAAA), National Institutes of Health (NIH), 5625 Fishers Lane, Rockville, Maryland 20852, United States.
Henry L PuhlLaboratory of Biophotonics and Quantum Biology, National Institute on Alcohol Abuse and Alcoholism (NIAAA), National Institutes of Health (NIH), 5625 Fishers Lane, Rockville, Maryland 20852, United States.
Sergio A HassanBioinformatics and Computational Biosciences Branch, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, Maryland 20892, United States.ORCID 0000-0003-3319-078X

Funding

Novel Cannabinoid Receptor ModulatorsZIAAA000360 · NIAAA · NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM · PI IYER, MALLIGA · 2021 to 2025
$5.9M
Intramural NIH HHS ZIA AA000360
6 · The paper itself

Abstract

Developing synthetic methods that allow controllable homologation to quickly access new chemical space is vital yet remains challenging for studying biological pathways. Utilizing underexplored elements as biological probes offers promising platforms to reveal uncharted aspects of G-protein-coupled receptor (GPCR) pharmacology. Here we report the development of an expeditious, sustainable platform for the scalable conversion of chloro-imidoylsulfonylureas, to provide one-pot access to synthetically versatile chiral, pro-chiral and achiral selenosulfonyl homologated compounds bearing the cannabinoid receptor-1 (CB

Indexed as

Receptor, Cannabinoid, CB1SeleniumMolecular StructureReceptor, Cannabinoid, CB1Selenium

Identifiers

PMID42046856
PMCPMC13185125

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.