SynthesisClinical and experimental dental research2026
Use of Platelet-Rich Platelet Aggregates (PRFs) in Soft Tissue Repair in Periodontics: A Systematic Review.
Synthesis in Clinical and experimental dental research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
10 authors.
Funding
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Abstract
objectivesTo evaluate, through a systematic review, the clinical effectiveness of platelet-rich fibrin (PRF) in periodontal soft tissue repair compared with conventional regenerative techniques. MATERIAL AND
methodsThis systematic review followed PRISMA 2020 guidelines and was registered in PROSPERO (CRD42024617061). Searches were conducted in PubMed, Scopus, Web of Science, ScienceDirect, and LILACS, complemented by gray literature sources. Randomized clinical trials evaluating PRF or its derivatives in periodontal soft tissue repair were included. From 996 identified records, 28 studies met the eligibility criteria and were included in the qualitative analysis.
resultsPRF demonstrated clinical outcomes comparable to conventional techniques such as connective tissue grafts and other biomaterials for root coverage and periodontal regeneration. In addition, PRF was associated with reduced surgical morbidity, lower postoperative discomfort, and shorter surgical time.
conclusionsPRF represents a promising autologous biomaterial for periodontal soft tissue repair, providing clinical outcomes similar to conventional grafting techniques with lower morbidity. Further well-designed clinical trials with standardized protocols and long-term follow-up are required.
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