SynthesisClinical and experimental dental research2026
Adjunctive Use of Locally Delivered Statins in Periodontal Therapy and Pre-Implant Bone Regeneration: A Systematic Review and Meta-Analysis.
Synthesis in Clinical and experimental dental research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Adjunctive Use of Locally Delivered Statins in Periodontal Therapy and Pre-Implant Bone Regeneration: A Systematic Review and Meta-Analysis.Clinical and experimental dental research · 2026Pooled it
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThis systematic review and meta-analysis aimed to evaluate the adjunctive beneficial effects of locally delivered statins on probing pocket depth (PPD), clinical attachment level (CAL), bleeding on probing (BoP), and radiographic bone outcomes in both periodontal therapy (Step 2 non-surgical periodontal therapy and Step 3 periodontal surgery) and pre-implant bone regeneration procedures.
methodsThe review followed the PRISMA 2020 statement and was registered in PROSPERO (CRD420251105739). PubMed and Scopus were searched through July 2025 for randomized controlled trials (RCTs) evaluating the adjunctive use of locally delivered atorvastatin (ATV), rosuvastatin (RSV), or simvastatin (SIM) in periodontal therapy and pre-implant regenerative procedures. Risk of bias was assessed using the Cochrane Risk of Bias 2 tool (RoB 2). Random-effects meta-analysis was conducted when extractable data were available at commonly reported follow-ups (6 months for Step 2; 9 months for Step 3).
resultsTwenty-one RCTs were included (13 Step 2, 6 Step 3, 2 pre-implant bone regeneration). In Step 2 therapy, adjunctive statins improved clinical outcomes compared with scaling and root planing alone, with pooled mean differences (MDs) of approximately 1.4-2.3 mm for PPD and 1.7-2.2 mm for CAL. Numerically larger pooled effects were observed for SIM; however, no direct head-to-head comparisons between statins were performed, and heterogeneity was high. In Step 3 therapy, three trials contributed to 9-month pooling, showing smaller but significant benefits (PPD MD 0.80 mm; CAL MD 0.69 mm), with moderate heterogeneity. Pre-implant bone regeneration trials were clinically heterogeneous and showed inconsistent radiographic outcomes, precluding quantitative synthesis.
conclusionsLocally delivered statins provide clinically relevant adjunctive benefits in Step 2 periodontal therapy and modest additional improvements in Step 3 therapy, particularly when incorporated into regenerative protocols. Evidence for pre-implant bone regeneration remains limited and heterogeneous. Further multicenter RCTs with standardized clinical and radiographic outcomes are needed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.