ArticleDiscoveries (Craiova, Romania)
The CuRe Trial: Groundbreaking Innovation Raising Scientific and Ethical Questions.
Article in Discoveries (Craiova, Romania). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
1 author.
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Abstract
Preliminary data for the Cellular Therapy for In Utero Repair of Myelomeningocele (CuRe) Trial have recently been published. These data showcase innovation in fetal surgery but introduce ethical questions regarding tissue sourcing. The CuRe Trial utilizes early gestational placental mesenchymal stromal/stem cells (PMSCs) in the repair technique. The ethical implications of this approach vary depending on whether they are sourced from miscarriage or elective abortion. The specific source of the PMSCs is unclear, but evidence suggesting that they might be sourced from elective abortion is presented, along with an overview of ethical implications if this is the case. Key questions considered include 1) whether research such as this is impacted by the recent decision by the National Institutes of Health (NIH) to cease funding of research using fetal tissue from elective abortion; 2) what ethical alternatives currently or may plausibly exist; and 3) whether scientific justifications exist for the use of tissue sourced from elective abortion over more ethical alternatives.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.