ArticleJournal of translational internal medicine2026
Lactate modulates microglial M2 polarization
Article in Journal of translational internal medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed.
- Roles of lactate and protein lactylation in neurogenesis and neurodegenerative disease.Journal of translational medicine · 2026Review
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and Objectives: Ischemic stroke triggers pathological neuroinflammation primarily mediated by microglial activation. However, the epigenetic impact of lactate, a metabolite that accumulates during cerebral ischemia, on this process has not been comprehensively investigated. This study aimed to determine whether lactate influences microglial polarization through histone lactylation during prolonged cerebral ischemia. Methods: Results: Under ischemic conditions, lactate markedly increased H3K9 lactylation, with selective enrichment at Nrf2 promoters. This epigenetic modification resulted in a phenotypic shift toward anti-inflammatory M2 states in microglia, both Conclusion: Our findings suggest that lactate confers neuroprotection
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