ArticleJournal of pain research2026
Clinical Outcomes of Pregabalin Therapy in Adults with Type I Complex Regional Pain Syndrome: A Case Series.
Article in Journal of pain research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
4 authors.
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Abstract
Background: Complex regional pain syndrome (CRPS) is a challenging pain disorder that may follow local trauma or central nervous system injury. Complex regional pain syndrome with identifiable nerve injury is classified as type II while cases without are classified as type I. Evidence regarding the effectiveness of pregabalin in treating complex regional pain syndrome remain limited. The study presents three cases of complex regional pain syndrome successfully treated with pregabalin. Methods: We retrospectively reviewed clinical data of patients diagnosed with complex regional pain syndrome at a single medical center in Taiwan between January 2022 and July 2025. Diagnosis was based on the Budapest criteria and confirmed with three-phase bone scintigraphy. Results: Three adult patients were included. All patients demonstrated clinical improvement in pain, quality of life, and rehabilitation adherence. One patient showed radiographic improvement on follow-up three-phase bone scan. Conclusion: Pregabalin appears to be a safe and potentially beneficial therapeutic option for complex regional pain syndrome and merits consideration as first-line pharmacotherapy within multidisciplinary treatment paradigms.
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