ArticleNeuro-oncology advances
Correlation between changes in substructure diffusion tensor imaging and neurocognitive outcomes for pediatric brain tumor survivors.
Article in Neuro-oncology advances. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Central nervous system (CNS) tumors are the second most common pediatric malignancy and the leading cause of cancer-related mortality in children. Although advances in therapy have improved survival, survivors experience neurocognitive decline related to tumor location, surgery, and radiation. Understanding how white matter integrity-assessed by diffusion tensor imaging (DTI)-relates to neurocognitive outcomes is essential for developing treatment-sparing strategies that preserve long-term function. Methods: This retrospective study included 171 neurocognitive assessments and at least 2 time-matched DTI scans from 68 pediatric brain tumor patients. Healthy controls ( Results: Longitudinal assessment revealed median annual declines in IQ and WMI. Changes in white matter diffusivity significantly correlated with neurocognitive outcomes, particularly within the cerebellum, cerebellar and cerebral peduncles, thalamus, and corpus callosum. Increases in λ Conclusion: Loss of white matter integrity was associated with neurocognitive decline in pediatric brain tumor survivors. These findings support the development of interventions aimed at preserving brain function and long-term quality of life by monitoring and mitigating factors associated with neurocognitive change.
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