Evidence map›Paper›PMID 42046762›Full record

ReviewInternational journal of microbiology2026

Co-Occurrence of Resistance to Aminoglycosides and Carbapenems in

Rafael Artur de Queiroz Cavalcanti de Sa, Tainara Fernandes Dantas, Sérgio Costa Júnior, Karolayne Oliveira da Silva, Maria Cecília Ferreira Galindo, Amanda Vieira de Barros, John Eversong Lucena de Vasconcelos, Radosław Kowalski, Grażyna Kowalska, Rafal Rowinski and 2 more

Abstract readReview
In one paragraph

Review in International journal of microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Co-Occurrence of Resistance to Aminoglycosides and Carbapenems inInternational journal of microbiology · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Rafael Artur de Queiroz Cavalcanti de SaDepartment of Biochemistry, Federal University of Pernambuco, Recife, Brazil, ufpe.br.ORCID https://orcid.org/0000-0002-0313-1482
Tainara Fernandes DantasDepartment of Biochemistry, Federal University of Pernambuco, Recife, Brazil, ufpe.br.ORCID https://orcid.org/0000-0001-9623-5135
Sérgio Costa JúniorDepartment of Biochemistry, Federal University of Pernambuco, Recife, Brazil, ufpe.br.ORCID https://orcid.org/0000-0002-2501-3284
Karolayne Oliveira da SilvaDepartment of Biochemistry, Federal University of Pernambuco, Recife, Brazil, ufpe.br.ORCID https://orcid.org/0000-0002-2909-8908
Maria Cecília Ferreira GalindoDepartment of Microbiology, University Center of Vitória de Santo Antão, Brazil.ORCID https://orcid.org/0009-0001-5447-5541
Amanda Vieira de BarrosDepartment of Biochemistry, Federal University of Pernambuco, Recife, Brazil, ufpe.br.ORCID https://orcid.org/0000-0001-8232-5711
John Eversong Lucena de VasconcelosDepartment of Dentistry, CECAPE College, Brazil.ORCID https://orcid.org/0000-0002-9555-8650
Radosław KowalskiDepartment of Analysis and Evaluation of Food Quality, University of Life Sciences in Lublin, Lublin, Poland, up.lublin.pl.ORCID https://orcid.org/0000-0003-3063-8710
Grażyna KowalskaDepartment of Tourism and Recreation, University of Life Sciences in Lublin, Lublin, Poland, up.lublin.pl.ORCID https://orcid.org/0000-0002-1872-2381
Rafal RowinskiDepartment of Tourism and Recreation, University of Life Sciences in Lublin, Lublin, Poland, up.lublin.pl.ORCID https://orcid.org/0000-0003-3908-9308
Henrique Douglas Melo CoutinhoDepartment of Biological Chemistry, Regional University of Cariri, Crato, Ceara, Brazil, urca.br.ORCID https://orcid.org/0000-0002-6634-4207
Maria Betânia Melo OliveiraDepartment of Biochemistry, Federal University of Pernambuco, Recife, Brazil, ufpe.br.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Antimicrobial resistance (AMR) in Klebsiella pneumoniae, especially the co-occurrence of resistance to aminoglycosides and carbapenems, represents a serious threat to global public health. This study reviews the prevalence of this combined resistance, analyzes the underlying mechanisms, and evaluates its impact on clinical practice and public health. To this end, a narrative literature review was carried out, using databases such as PubMed, SciELO, Google Scholar, DOAJ, Virtual Health Library (VHL), and ScienceDirect. Studies published in the last 10 years in English and Portuguese, related to resistance to these two drugs in K. pneumoniae, were included. The qualitative analysis of the data revealed an alarming increase in the prevalence of resistant strains, mainly associated with the production of Aminoglycoside Modifying Enzymes (AME) and carbapenemases, resulting in significantly high rates of mortality, morbidity, and treatment costs. To mitigate this threat, multifaceted strategies are needed, such as the rational use of antibiotics, epidemiological surveillance, education programs, and investment in research for new antimicrobials. In addition, it is observed that multisectoral collaboration is essential to face this challenge, requiring coordinated and continuous efforts in research, education, and public health practices.

Indexed as

antibioticsantimicrobial resistanceepidemiologynosocomial infections

Identifiers

PMID42046762
PMCPMC13110393

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.