ArticleVeterinary world2026
Comparative effects of insulin-like growth factor-1, lycopene, and α-tocopherol on mitochondrial dynamics and developmental competence of buffalo (
Article in Veterinary world, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background and Aim: In Materials and Methods: A total of 1,485 high-quality buffalo oocytes were subjected to Results: The nuclear maturation rate (metaphase II stage) was significantly higher (p < 0.01) in the IGF-1 and lycopene groups (85.2% and 87.3%, respectively) compared with the control (73.3%) and α-tocopherol groups (76.2%). Cleavage, morula, and blastocyst formation rates were also significantly higher (p < 0.01) in the IGF-1 (89.3%, 28.5%, and 20.6%) and lycopene (84.2%, 30.8%, and 32.7%) groups than in the control (75.1%, 20.3%, and 12.2%) and α-tocopherol (76.7%, 23.2%, and 14.4%) groups. Lycopene produced the highest blastocyst yield. Mitochondrial fluorescence intensity was significantly greater (p < 0.01) in all supplemented groups compared with the control. Diffuse mitochondrial distribution predominated in IGF-1- and lycopene-treated oocytes, indicating improved cytoplasmic competence and metabolic activity, whereas α-tocopherol treatment was associated with increased peripheral mitochondrial localization. Conclusion: Supplementation of IVM medium with 100 ng/mL IGF-1 or 0.2 μM lycopene significantly enhances nuclear maturation, mitochondrial activity, and embryo developmental competence of buffalo oocytes. Lycopene demonstrated the most pronounced improvement in blastocyst formation, suggesting superior antioxidant protection during maturation. These findings highlight the importance of optimizing mitochondrial function and oxidative balance in buffalo IVEP systems and provide a potential strategy to improve reproductive biotechnology outcomes in buffalo.
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