ArticleVeterinary world2026
Integrated molecular, immunoinformatic, and structural analysis reveals emerging antigenic divergence of Foot-and-mouth disease virus serotype O during the 2022-2023 outbreaks in Indonesia.
Article in Veterinary world, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and Aim: After more than three decades of freedom from foot-and-mouth disease (FMD), Indonesia experienced widespread outbreaks in 2022-2023, raising major concerns regarding viral evolution and vaccine effectiveness. Foot-and-mouth disease virus (FMDV) serotype O remains the predominant circulating serotype in the region. However, the immunological and structural consequences of recent genetic variation have not been comprehensively evaluated. This study aimed to integrate molecular, immunoinformatic, and structural analyses to characterize FMDV serotype O isolates from West Java and South Sumatra and to assess their implications for antigenicity, immune recognition, and vaccine matching. Materials and Methods: Clinical epithelial samples were collected from naturally infected cattle during outbreaks in West Java and South Sumatra. Viral RNA was extracted, and the capsid genes Results: Sequence comparison revealed reduced identity of Conclusion: This integrated molecular-immunoinformatic-structural analysis demonstrates that newly circulating Indonesian FMDV serotype O isolates exhibit genetic, antigenic, and structural divergence that may reduce current vaccine matching. Continuous molecular surveillance and regionally adapted vaccine design are therefore essential to maintain effective FMD control in Indonesia.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.