Evidence map›Paper›PMID 42046659›Full record

ArticleDepression and anxiety2026

Abnormal Activation and Connection in Middle Frontal Gyrus: A Potential Imaging Feature for Facial Synkinesis Comorbid Depression.

Haonan Guan, Luyao Wang, Fan Dong, Wenjing Hu, Zhilin Zhang, Jinglong Wu, Yue Lu, Wei Ding, Jiehui Jiang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Depression and anxiety, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Haonan GuanDepartment of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200011, China, shsmu.edu.cn.
Luyao WangInstitute of Biomedical Engineering, School of Life Sciences, Shanghai University, Shanghai, 200444, China, shu.edu.cn.
Fan DongInstitute of Biomedical Engineering, School of Life Sciences, Shanghai University, Shanghai, 200444, China, shu.edu.cn.
Wenjing HuInstitute of Biomedical Engineering, School of Life Sciences, Shanghai University, Shanghai, 200444, China, shu.edu.cn.
Zhilin ZhangResearch Center for Medical Artificial Intelligence, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, Guangdong, China, cas.cn.ORCID 0000-0002-2442-0478
Jinglong WuSchool of Medical Technology, Beijing Institute of Technology, Beijing, 100081, China, bit.edu.cn.
Yue LuDepartment of Neurology, Shanghai Changhai Hospital, Shanghai, China, chhospital.com.cn.
Wei DingDepartment of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200011, China, shsmu.edu.cn.ORCID 0000-0002-3280-3575
Jiehui JiangInstitute of Biomedical Engineering, School of Life Sciences, Shanghai University, Shanghai, 200444, China, shu.edu.cn.ORCID 0000-0003-4948-3683

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Patients with facial synkinesis (FS) comorbid depression may experience aggravated symptoms of perceived synkinesis and poorer recovery outcomes. Exploring imaging features associated with depressive symptoms could help us better understand disease conditions and formulate appropriate rehabilitation plans. Although abnormal activation in the middle frontal gyrus (MFG) has been reported in depression patients, whether it represents an imaging correlate of depressive symptoms in patients with FS is still unknown. Therefore, a total of 52 participants (20 normal controls [NCs], 32 patients) with both task and resting-state functional magnetic resonance imaging (rs-fMRI) data were included in this study. Comorbid depression was assessed with the Diagnostic and Statistical Manual of Mental Disorders, 5th edition (DSM-V), and depressive symptom severity was measured with the Beck Depression Inventory-II (BDI-II). We investigated brain activation during motor tasks (smiling, blinking, and grinning). In addition, the seed-based functional connectivity (FC) between the MFG and other brain areas was calculated in the resting state. Additionally, we analyzed the associations between brain activity and clinical scale scores. The results revealed reduced activation in the sensorimotor and MFG during affected side movements across all tasks (voxel-level

Indexed as

ConnectomeDepressionDepressive DisorderPrefrontal CortexSynkinesisAdultComorbidityFacial ExpressionFemaleHumansMagnetic Resonance ImagingMaleMiddle Agedbrain activationdepressionfunctional connectivitytask fMRI

Identifiers

PMID42046659
PMCPMC13110137

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.