ArticleCureus2026
Recurrent Seizure-Triggered Takotsubo Syndrome With Phenotypic Switching and Rapid Functional Recovery: A Case Report.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Takotsubo syndrome (TTS) is an acute cardiomyopathy characterized by transient left ventricular systolic dysfunction, often mimicking acute coronary syndrome. Current pathophysiological concepts emphasize sympathetic overactivity and catecholamine excess as major determinants of myocardial stunning, and experimental models further suggest that high epinephrine concentrations may induce a beta-2 adrenoceptor Gs-to-Gi signaling switch, contributing to severe but reversible myocardial dysfunction. Neurological triggers, particularly epileptic seizures, are increasingly recognized and may be associated with distinctive clinical profiles, arrhythmic complications, recurrence, and variable ventricular morphology. We report the case of a 57-year-old woman with epilepsy and chronic obstructive pulmonary disease who presented with acute chest pain immediately after a generalized tonic-clonic seizure. She had experienced a previous TTS episode 11 months earlier, documented as a mid-ventricular variant with a left ventricular ejection fraction (LVEF) of 50%. During the recurrent episode, electrocardiography showed sinus rhythm without ST-segment elevation, with known anteroseptal T-wave inversion. Serial laboratory testing demonstrated a relatively modest peak high-sensitivity troponin T level of 140 pg/mL despite severe left ventricular dysfunction, together with markedly elevated N-terminal pro-B-type natriuretic peptide. Transthoracic echocardiography showed an LVEF of 20%-25%, with apical hypokinesia extending to the adjacent mid-ventricular segments and relative basal hypercontractility. Coronary angiography showed no acute culprit lesion and was unchanged from the prior examination. Left ventriculography confirmed apical ballooning with mid-ventricular extension. By day 3, LVEF had improved to 52%, while cardiac magnetic resonance imaging showed normalized wall motion with mild residual myocardial edema. This case highlights recurrent seizure-triggered TTS with documented phenotypic switching and rapid functional recovery, emphasizing the value of multimodality imaging and coordinated neuro-cardiac management.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.