ArticleCureus2026
Age-Related Changes in the Nasolabial Angle and Anterior Nasal Spine: A Three-Dimensional Morphometric Study Using Skull Computed Tomography (CT) Scans.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
introductionThe anterior nasal spine (ANS) is a thin bony structure located in the maxilla that plays a crucial role in supporting the nasal apex and upper lip, serving as an important reference point in dental and surgical procedures, as well as in craniofacial analyses. Age-related changes, such as bone remodeling, can influence its morphology and, consequently, modify the nasolabial angle, a relevant parameter for assessing aesthetic and functional changes in the face. The objective of this study was to investigate possible changes in the nasolabial angle with advancing age through three-dimensional morphometric analysis of computed tomography scans of human skulls.
methodsThe sample consisted of 93 CT scans. Based on age, the individuals were classified into three groups: 18-44 years (young), 45-64 years (middle-aged), and ≥65 years (elderly). The images were segmented using Mimics 18.0 software, allowing three-dimensional reconstruction of the ANS and measurement of the nasolabial angle from three specific anatomical landmarks. Statistical analysis was performed using ANOVA, followed by a Šídák multiple comparisons test, adopting a 5% significance level.
resultsThe results demonstrated that the nasolabial angle presented significant changes from the young male group vs. the middle-aged female group, tending to become more closed with aging. Furthermore, morphological variations of the ANS (single, bifid, or double) were identified, highlighting its anatomical diversity.
conclusionIt is concluded that the ANS undergoes structural modifications throughout adulthood, as reflected in the nasolabial angle, and that it is a relevant landmark in studies of facial aging, in addition to its clinical value in dental and surgical procedures.
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