ArticleCureus2026
Beyond the Petri Dish: The Performance of a Multiplex PCR-Based Pneumonia Panel in Hospitalized Patients With Lower Respiratory Tract Infection.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
6 authors.
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Abstract
Background Lower respiratory tract infections (LRTIs) are a major cause of mortality in intensive care units (ICUs), necessitating rapid pathogen identification. This study evaluates the diagnostic performance of the multiplex polymerase chain reaction (PCR)‑based BioFire® FilmArray® Pneumonia Panel (BFPP) compared to conventional culture in hospitalized patients with LRTI at a tertiary care center. Methodology This retrospective observational study was carried out at a tertiary care hospital between January 2023 and June 2024. Bronchoalveolar lavage (BAL) culture and antibiotic sensitivity testing (ABST) data of individuals suspected to have LRTI were retrieved and compared to BFPP results for concordance. Results A total of 261 bronchoalveolar lavage (BAL) specimens were analyzed using the BFPP. Overall, BFPP detected 562 pathogens, comprising 419 bacterial isolates, 139 viral pathogens, and four atypical bacteria. Polymicrobial infections were identified in 33% of the specimens. Among the antimicrobial resistance determinants detected, New Delhi metallo‑β‑lactamase (
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