Multiparametric Pelvic-Floor Magnetic Resonance Imaging for the Staging of Anterior-Compartment Clinical Pelvic Organ Prolapse: A Prospective Study.

Objective: This study aimed to evaluate the utility of multiparametric pelvic-floor magnetic resonance imaging (MRI) for identifying stage III-IV anterior-compartment clinical pelvic organ prolapse (POP) and guiding clinical management. Methods: In total, 123 women with confirmed anterior-compartment clinical POP were prospectively categorized into non-stage III-IV (n = 60) and stage III-IV (n = 63) groups. All participants underwent combined pelvic-floor Results: Compared with the non-stage III-IV group, the stage III-IV group was significantly older in age; had higher Pelvic Floor Distress Inventory-20 scores; exhibited larger B-PCL, M-line, and LHA values at maximum Valsalva; and demonstrated lower pubovisceral muscle T2* values. Compared with the "rule of three", the optimal multiparametric MRI-based model achieved an area under the curve of 0.802, with significantly higher sensitivity, modestly lower specificity, and superior overall accuracy. Conclusion: The multiparametric pelvic-floor MRI-based diagnostic model demonstrates superior performance in identifying stage III-IV anterior-compartment clinical POP. This model provides an objective imaging-based reference to support accurate POP staging and guide clinical management.