Evidence map›Paper›PMID 42046555›Full record

ArticleOpen life sciences2026

Lower serum uric acid levels as a risk factor for depression in prodromal Parkinson's disease: a cohort study.

Keke Liang, Yetong Ouyang, Bingyu Li, Tao Li, Jun Tan, Chenxi Shuai, Xiaohui Tang, Zhilin Chen, Zhexue Huang, Xiaoshun Tang and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Open life sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

15 authors.

Keke LiangDepartment of Neurology, Shanghai Tongji Hospital, School of Medicine, Tongji University, Shanghai 200065, China.ORCID https://orcid.org/0000-0002-0024-4772
Yetong OuyangDepartment of Neurology, Shanghai Tongji Hospital, School of Medicine, Tongji University, Shanghai 200065, China.
Bingyu LiDepartment of Neurology, Shanghai Tongji Hospital, School of Medicine, Tongji University, Shanghai 200065, China.
Tao LiDepartment of Neurology, Shanghai Tongji Hospital, School of Medicine, Tongji University, Shanghai 200065, China.
Jun TanDepartment of Neurology, Shanghai Tongji Hospital, School of Medicine, Tongji University, Shanghai 200065, China.
Chenxi ShuaiDepartment of Neurology, Shanghai Tongji Hospital, School of Medicine, Tongji University, Shanghai 200065, China.
Xiaohui TangDepartment of Neurology, Shanghai Tongji Hospital, School of Medicine, Tongji University, Shanghai 200065, China.ORCID https://orcid.org/0000-0003-2500-3649
Zhilin ChenDepartment of Neurology, Shanghai Tongji Hospital, School of Medicine, Tongji University, Shanghai 200065, China.
Zhexue HuangDepartment of Neurology, Shanghai Tongji Hospital, School of Medicine, Tongji University, Shanghai 200065, China.
Xiaoshun TangDepartment of Neurology, Shanghai Tongji Hospital, School of Medicine, Tongji University, Shanghai 200065, China.
Jiayi JinDepartment of Neurology, Shanghai Tongji Hospital, School of Medicine, Tongji University, Shanghai 200065, China.
Qian LiangDepartment of Neurology, Shanghai Tongji Hospital, School of Medicine, Tongji University, Shanghai 200065, China.
Zhengchen LiDepartment of Neurology, Shanghai Tongji Hospital, School of Medicine, Tongji University, Shanghai 200065, China.
Qing-Ran BaiKey Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of Ministry of Education, Department of Orthopedics, Tongji Hospital, School of Medicine, Tongji University, Shanghai 200092, China.ORCID https://orcid.org/0000-0002-3787-8445
Xijin WangDepartment of Neurology, Shanghai Tongji Hospital, School of Medicine, Tongji University, Shanghai 200065, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Depression, as an important prodromal non-motor manifestation of Parkinson's disease (PD), its early predictive indicators remain unclear. Although cross-sectional studies suggest an association between serum uric acid (UA) levels and depression in PD, longitudinal evidence in the prodromal period is lacking. This study innovatively conducted a 5-year longitudinal study in a population with prodromal Parkinson's disease (pPD), revealing for the first time the longitudinal association between serum UA levels and the development of depression. At baseline, we selected 460 pPD patients from the Parkinson's Progression Markers Initiative (PPMI) database. Eventually, 61 participants completed a 5-year longitudinal study with annual assessments. Predictor variables were selected through univariate Cox analysis and LASSO regression, with multivariate Cox regression models employed to assess the independent association between serum UA levels and incident depression in the pPD cohort. At baseline, 18.9 % of pPD patients developed depression, and the cumulative incidence rates of depression during the 5-year follow-up period were 34.43 %, 49.18 %, 57.38 %, 62.30 % and 63.93 %, respectively. Multivariate Cox regression analysis, adjusted for covariates including sex and age, identified a higher Movement Disorder Society Unified Parkinson's Disease Rating Scale Part I (MDS-UPDRS I) score (HR = 1.177, 95 % CI 1.093-1.267,

Indexed as

depressionprodromal Parkinson’s diseaserisk factorserum uric acid

Identifiers

PMID42046555
PMCPMC13110254

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.