ArticleJournal of animal physiology and animal nutrition2026
Dietary Omega-3 Fatty Acids Alter Hepatic Lipid Oxidation and Oxidative Stress Markers in Postpartum Dairy Cows.
Article in Journal of animal physiology and animal nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Dietary Omega-3 Fatty Acids Alter Hepatic Lipid Oxidation and Oxidative Stress Markers in Postpartum Dairy Cows.Journal of animal physiology and animal nutrition · 2026Article
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7 authors.
Funding
Abstract
Omega-3 (ω-3) polyunsaturated fatty acids are well recognized for their potential to influence metabolic adaptation in dairy cows during the transition period. This study evaluated the effects of calcium salts enriched with ω-3 fatty acids, including α-linolenic acid and long-chain ω-3 fatty acids such as eicosapentaenoic and docosahexaenoic acids, on hepatic lipid metabolism-related proteins, oxidative stress biomarkers, and liver function in postpartum dairy cows. Prior to calving, cows received a total mixed ration supplemented with 0.400 kg dry matter (DM)/day of calcium salts derived from a flaxseed oil-fish oil mixture (60:40). After calving, cows were fed a partial mixed ration and received 0.650 kg DM/day of the same supplement mixed with a commercial concentrate during milking. Control cows received isoenergetic diets in which calcium salts were replaced with ground corn. Blood, urine, and liver samples were collected at -21 days relative to calving (used as a baseline covariate) and at +7, and +21 (±3) days postpartum, when treatment effects were evaluated. No differences were observed between treatments in conventional biochemical markers of liver function or hepatic triacylglycerol concentration. Plasma malondialdehyde concentrations were higher in ω-3-supplemented cows, whereas other oxidative stress parameters were not affected. Supplementation with ω-3 fatty acids was associated with changes in the abundance of selected hepatic proteins involved in fatty acid metabolism, including increased acyl-CoA oxidase 1 and 3-hydroxy-3-methylglutaryl-CoA synthase and reduced diacylglycerol O-acyltransferase 1 abundance, whereas carnitine palmitoyltransferase 1 and peroxisome proliferator-activated receptor alpha abundance were not affected. These findings indicate that ω-3-enriched calcium salts induce molecular adjustments in hepatic lipid metabolism during early lactation without evidence of adverse effects on liver function.
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