Evidence map›Paper›PMID 42046335›Full record

ArticleJournal of diabetes research2026

Zizhu Ointment Inhibits IgE-FcεRI Signaling-Mediated Mast Cell Degranulation to Promote the Healing of Diabetic Foot Ulcers.

Jian Sun, Xiaoqian Zhang, Meijie Yuan, Xiao Yang, Lei Wang, Hongshuo Shi, Guobin Liu, Yang You

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of diabetes research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jian SunDepartment of Vascular Surgery, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China, shutcm.edu.cn.ORCID https://orcid.org/0000-0001-9645-4741
Xiaoqian ZhangDepartment of Vascular Surgery, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China, shutcm.edu.cn.
Meijie YuanDepartment of Vascular Surgery, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China, shutcm.edu.cn.ORCID https://orcid.org/0000-0003-0951-8271
Xiao YangDepartment of Vascular Surgery, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China, shutcm.edu.cn.
Lei WangThe Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, China, bucm.edu.cn.ORCID https://orcid.org/0000-0002-2013-0705
Hongshuo ShiDepartment of Vascular Surgery, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China, shutcm.edu.cn.ORCID https://orcid.org/0000-0003-0012-5869
Guobin LiuDepartment of Vascular Surgery, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China, shutcm.edu.cn.ORCID https://orcid.org/0000-0002-6031-6301
Yang YouDepartment of Vascular Surgery, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China, shutcm.edu.cn.ORCID https://orcid.org/0000-0002-7680-1731

Funding

National Natural Science Foundation of China 82274528Science and Technology development Fund project of Shanghai University of Traditional Chinese Medicine 24KFL070Scientific Research Project of Shanghai Municipal Health Commission 202240228
6 · The paper itself

Abstract

Diabetic ulcers, a serious complication associated with diabetes, present a significant therapeutic challenge due to their recurrent and persistent chronic inflammation. A crucial factor contributing to this sustained inflammation is mast cell degranulation. This study examined the effects of the traditional Chinese herbal formula Zizhu ointment (ZZO) on mast cell degranulation in diabetic ulcers, as well as its underlying mechanisms in promoting wound healing. Analysis of clinical specimens revealed that ZZO significantly inhibited mast cell degranulation in diabetic ulcer wounds. In a diabetic mouse wound model, ZZO was observed to suppress mast cell degranulation, decrease the expression of TNF-α and MMP-9, and facilitate wound healing. Cellular experiments demonstrated that ZZO inhibited IgE/DNP cross-linking-mediated degranulation, calcium (Ca

Indexed as

Cell DegranulationDiabetic FootDrugs, Chinese HerbalImmunoglobulin EMast CellsReceptors, IgEWound HealingAnimalsDiabetes Mellitus, ExperimentalHumansMaleMiceOintmentsSignal TransductionTumor Necrosis Factor-alphaDrugs, Chinese HerbalImmunoglobulin EOintmentsReceptors, IgETumor Necrosis Factor-alphadegranulationdiabetic foot ulcerigE-fcεRI signalingmast cellzizhu ointment

Identifiers

PMID42046335
PMCPMC13121867

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.