Evidence map›Paper›PMID 42046285›Full record

Trial reportJournal of the International Society of Sports Nutrition2026

Bifidobacterium longum BB536 is associated with improvements in gastrointestinal symptoms and odor-related metabolites in microbiota-defined subgroups of male athletes consuming a high-protein diet: exploratory randomized double‑blind placebo‑controlled trial.

Shu Miyamoto, Shin Yoshimoto, Noriko Katsumata, Natsumi Mutoh, Noriyuki Iwabuchi, Toshitaka Odamaki, Daisuke Asaoka, Shuichi Machida

Erratum issuedAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of the International Society of Sports Nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Effects of Heat-KilledNutrients · 2026
    Trial
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Shu MiyamotoBiotics Research Institute, Morinaga Milk Industry Co., Ltd., Zama-City, Kanagawa, Japan.
Shin YoshimotoBiotics Research Institute, Morinaga Milk Industry Co., Ltd., Zama-City, Kanagawa, Japan.
Noriko KatsumataBiotics Research Institute, Morinaga Milk Industry Co., Ltd., Zama-City, Kanagawa, Japan.
Natsumi MutohBiotics Research Institute, Morinaga Milk Industry Co., Ltd., Zama-City, Kanagawa, Japan.
Noriyuki IwabuchiBiotics Research Institute, Morinaga Milk Industry Co., Ltd., Zama-City, Kanagawa, Japan.
Toshitaka OdamakiBiotics Research Institute, Morinaga Milk Industry Co., Ltd., Zama-City, Kanagawa, Japan.
Daisuke AsaokaDepartment of Gastroenterology, Juntendo Tokyo Koto Geriatric Medical Center, Tokyo, Japan.
Shuichi MachidaGraduate School of Health and Sports Science, Juntendo University, Inzai, Chiba, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHigh‑protein diets are widely used by athletes but may disturb the gut environment and increase production of odor‑related metabolites. Probiotic supplementation has been proposed as a strategy to support gastrointestinal function under such dietary stress. This study aimed to explore the effects of

methodsIn an exploratory, randomized, double‑blind, placebo‑controlled trial, 60 healthy male athletes (mean age: 18.62 ± 0.75 years; mean BMI: 22.35 ± 1.80 kg/m

resultsIn the overall cohort, no significant between‑group differences were observed across gastrointestinal outcomes, gut microbiota indices, or metabolite profiles. Within the BB536 group, diarrhea‑related scores improved from baseline. Post hoc analyses suggested that increases in

conclusionBB536 supplementation was associated with improvements in diarrhea‑related symptoms and odor‑related metabolites in specific microbiota‑defined subgroups. As these findings did not extend to the full cohort, they should be interpreted as exploratory and hypothesis‑generating. Baseline gut microbiota composition may influence probiotic responsiveness, warranting confirmatory trials with prespecified endpoints.

Indexed as

Bifidobacterium longumDiet, High-ProteinGastrointestinal MicrobiomeOdorantsProbioticsAdolescentAthletesDouble-Blind MethodFecesHumansMaleVolatile Organic CompoundsWhey ProteinsVolatile Organic CompoundsWhey ProteinsAthletesbody odordiarrhea-related symptomshigh-protein dietmicrobiome stratification

Identifiers

PMID42046285
PMCPMC13126944

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.