ArticleThe American journal on addictions2026
Brief Report: Is once daily enough? Assessing the impact of timing of methadone dose on pain sensitivity via quantitative sensory testing in persons with opioid use disorder.
Article in The American journal on addictions, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 authors.
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Abstract
BACKGROUND AND
objectivesOnce-daily methadone dosing for opioid use disorder (OUD) may leave periods of inadequate analgesia. We tested whether experimental pain sensitivity differs across the inter-dose interval.
methodsTwenty-five adults (52% female, 43.12 years old) with OUD receiving stable once-daily methadone completed thermal quantitative sensory testing at early post-dose and pre-dose.
resultsHeat pain threshold (MD -3.75°C; g = -0.78; p < .001) and tolerance (MD -0.92°C; g = -0.49; p = .018) were lower at pre-dose. Temporal summation and conditioned pain modulation did not differ. DISCUSSION AND
conclusionsPain sensitivity increased pre-dose, consistent with a hyperalgesic window. SCIENTIFIC SIGNIFICANCE: Preliminary experimental evidence that once-daily methadone may contribute to cyclical hyperalgesia in persons with OUD.
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