ArticleBMC nutrition2026
Insulin resistance and lower insulin sensitivity: significant contributors to weight regain in non-menopausal Iranian women.
Article in BMC nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Weight regain after weight loss due to dietary interventions is a complex and prevalent issue in weight management. Insulin resistance plays a potentially significant role in this issue. In this cross-sectional study, we investigated the association between serum insulin levels, insulin resistance, and fasting blood sugar (FBS) with weight regain among non-menopausal Iranian women. Our analysis on 146 patients who have passed one-year dietary treatment, revealed significant differences between the weight regain and weight maintenance groups. Mean insulin concentration (p = 0.02), FBS (p < 0.001), and insulin resistance (p = 0.01), were significantly higher in the weight regain group, however, insulin sensitivity was lower (p < 0.001). These findings suggest a positive correlation between elevated insulin levels, FBS, and insulin resistance, with body mass index one-year post-intervention. This study underscores the potential role of these metabolic factors in weight regain, providing valuable insights for weight management strategies.
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