Trial reportBMC oral health2026
Effectiveness of omega-3 poly unsaturated fatty acids on the treatment of gingival hyperpigmentation: a randomized controlled clinical trial.
Trial report in BMC oral health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07067515 (Effectiveness of Omega-3 Poly Unsaturated Fatty Acids on The Treatment of Gingival Hyperpigmentation), which is not on this map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Effectiveness of Omega-3 Poly Unsaturated Fatty Acids on The Treatment of Gingival Hyperpigmentation: A Randomized Controlled Clinical Trial
Who cites it
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn dentistry, gingival hyperpigmentation is a common aesthetic issue caused mainly by excessive melanin deposits. Traditional surgical methods for depigmentation, like surgical techniques, can be effective, but they often associated with pain after the procedure and longer healing times. Because of their anti-inflammatory and antioxidant qualities, omega-3 polyunsaturated fatty acids (PUFAs) have demonstrated potential benefits in tissue regeneration and dermatological depigmentation.
objectiveTo investigate the effectiveness of locally and systemically administered Omega-3 (PUFAs) in reducing gingival pigmentation, thereby contributing to advancements in aesthetic periodontal care. METHODOLOGY: Two groups were randomly selected from thirty patients who presented with mild to moderate gingival pigmentation grade (1,2 or 3) in the maxillary esthetic area. Group I was given a daily oral dose of 2 g of Omega-3 PUFAs before and after one weekly intragingival injections of 1–2 g of omega-3. Group II was depigmented using a traditional surgical technique. At one, three, and six months, the primary outcome Dummett Oral Pigmentation Index (DOPI). Secondary outcomes Hedin index measured at 1,3,6 months, Visual Analogue Scale (VAS) and wound healing were measured at one and seven days following the procedure. Hemorrhage during the surgery were also noted.
resultsBoth groups displayed a significant decrease (P ≤ 0.05) in the DOPI and Hedin index at various time points. However, after six months, there was no significant difference between the groups (P ≥ 0.05). When compared to Group II at various time points, group I displayed a statistically significant decrease (P ≤ 0.05) in VAS, hemorrhage, and wound healing. gingival pigmentation.
conclusionOmega-3 PUFAs oral mesotherapy is a minimally invasive, safe, and aesthetically acceptable alternative to surgical depigmentation. Its antimelanognic activity makes it a good option for gingival hyperpigmentation treatment.
trial registrationThis research was officially registered in clinicaltrial.gov (NCT07067515) on (15/7/2025).
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