Trial reportBMC neurology2026
Effects of multisession frontoparietal network anodal tDCS and cognitive rehabilitation on subjective cognitive impairment: a double-blind RCT.
Trial report in BMC neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
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Authors and funding
6 authors.
Funding
Abstract
Repeated sessions of cognitive training and anodal transcranial direct current stimulation (tDCS) have the potential to enhance cognition in patients with subjective cognitive impairment (SCI). We hypothesized that this combination would improve memory function and reduce subjective complaints in SCI patients. In a randomized sham-controlled double-blind study, 35 SCI patients (ages 35–50) were assigned to one of two intervention groups in a 1:1 ratio using a computer-generated random number sequence. The intervention consisted of 10 sessions of cognitive training over three weeks, with concurrent 2-mA anodal tDCS over the left dorsolateral prefrontal cortex and left posterior parietal cortex. 30 participants completed the intervention and were included in the final analysis. The primary outcome variables were the scores on computerized tests of the Cambridge Neuropsychological Test Automated Battery (CANTAB). Secondary outcomes included scores on tests evaluating general cognition using the Montreal Cognitive Assessment (MOCA), sleep quality, anxiety, depression, and degree of subjective complaints. Changes in scores during the study period were compared between groups. The study was completed by 35 participants with SCI. The real tDCS group showed significantly better CANTAB scores compared to the sham group (p < 0.05). General cognition (MOCA) scores did not differ between groups, but mood and sleep quality improved significantly in the real tDCS group. In conclusion, our trial suggests that cognitive training combined with anodal tDCS was associated with significantly enhanced performance and reduced subjective complaints in SCI patients. Future research should explore individualized protocols for optimizing treatment.Trial registration The clinical trial registration code was obtained from the Iranian Registry of Clinical Trials (IRCT20181109041598N2).
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.