The role of alternative splicing in gastric cancer.

Qichen Huang, Junyu Ke, Xinrui Shen, Yitian Xu, Sijun Sun, Chen Huang

Abstract readReview

In one paragraph

Review in Biology direct, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Qichen Huang *Department of Gastrointestinal Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China.

Junyu Ke *Department of Gastrointestinal Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China.

Xinrui Shen *Department of Gastrointestinal Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China.

Yitian XuDepartment of Gastrointestinal Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China.

Sijun SunDepartment of Gastrointestinal Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China.

Chen HuangDepartment of Gastrointestinal Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China. richard-hc@hotmail.com.

Funding

National Natural Science Foundation of China 82472921

6 · The paper itself

Abstract

Gastric cancer (GC) remains a major cause of cancer incidence and mortality worldwide. Alternative splicing (AS), a post-transcriptional mechanism that expands transcript diversity from a single pre-mRNA, plays critical regulatory roles in GC. This review summarizes the current knowledge of AS in GC. Accumulating evidence shows that aberrant AS contributes to the oncogenesis, progression, invasion, metastasis and drug resistance of GC. In addition, AS-related biomarkers like RBM4 and prognostic models for subtype prediction have been reported. However, most existing studies have focused on basic research, while patient-level validation remains limited and standardized detection and analytical workflows are still lacking. Future work should prioritize prospective cohorts and standardized pipelines.

Indexed as

Alternative SplicingStomach NeoplasmsGene Expression Regulation, NeoplasticHumansAlternative splicingGastric cancerRNA processingSplicing variant

Identifiers

PMID42045977

DOI10.1186/s13062-026-00813-4

PMCPMC13251025

What OpenQuestion holds

Textmetadata

LicenceCC BY-NC-ND

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.