Evidence map›Paper›PMID 42045957›Full record

ArticleJournal of nanobiotechnology2026

Sea cucumber-inspired dual-responsive black phosphorus/amorphous calcium-based bone-targeting nanoplatform for synergistic therapy of osteoporosis.

Xiang Shen, Zixun Lan, Yaqiong Zhu, Tingting Zhong, Bozhang Li, Jiaheng Chen, Yanglong Zhu, Jing Ye, Xiaolei Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xiang Shen *School of Chemistry and Chemical Engineering, Nanchang University, Nanchang, 330031, Jiangxi, P. R. China.
Zixun Lan *The National Engineering Research Center for Bioengineering Drugs and the Technologies, Institute of Translational Medicine, Nanchang University, Nanchang, 330088, Jiangxi, P. R. China.
Yaqiong Zhu *Department of Otolaryngology-Head and Neck Surgery, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, 330006, Jiangxi, P. R. China.
Tingting Zhong *School of Chemistry and Chemical Engineering, Nanchang University, Nanchang, 330031, Jiangxi, P. R. China.
Bozhang LiSchool of the Second Clinical Medicine, Nanchang University, Nanchang, 330036, Jiangxi, P. R. China.
Jiaheng ChenSchool of Chemistry and Chemical Engineering, Nanchang University, Nanchang, 330031, Jiangxi, P. R. China.
Yanglong ZhuDepartment of Plastic Surgery, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, 330006, Jiangxi, China.
Jing YeDepartment of Orthopaedics, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, 330006, Jiangxi, P. R. China. yejing12311@163.com.
Xiaolei WangSchool of Chemistry and Chemical Engineering, Nanchang University, Nanchang, 330031, Jiangxi, P. R. China. wangxiaolei@ncu.edu.cn.

Funding

he Ganpo Talent Support Program-Leading Academic and Technical Personnel in Major Disciplines of Jiangxi Province 20243BCE51143Innovative Research Group Project of the National Natural Science Foundation of China 32560229Innovative Research Group Project of the National Natural Science Foundation of China 82360220Innovative Research Group Project of the National Natural Science Foundation of China 82360424the Ganpo Talent Support Program-Leading Academic and Technical Personnel in Major Disciplines of Jiangxi Province 20243BCE51164the Interdiscipline Innovation Fund Project of Nanchang University PYJX20230001the Jiangxi Province Key Laboratory of Bioengineering Drugs 2024SSY07061the Key Project of Science and Technology Innovation of Jiangxi Health Commission 2025ZD011the Key Research and Development Program of Jiangxi Province 20212BBG73004the Natural Science Foundation of Jiangxi Province for Distinguished Young Scholars 20242BAB23078the Youth Fund Project of Natural Science Foundation of Jiangxi Province 20224BAB216031the Youth Fund Project of Natural Science Foundation of Jiangxi Province 20224BAB216050
6 · The paper itself

Abstract

The core pathological mechanism of osteoporosis (OP) resides in the imbalance between osteoblast-mediated bone formation and osteoclast-mediated bone resorption. Furthermore, the accumulation of reactive oxygen species (ROS) and pro-inflammatory factors in bone tissue induces disorders in the immune microenvironment, which substantially elevates the risk of fracture. Inspired by the biological behaviors of sea cucumbers, we designed and constructed a bone-targeting platform (BA@PDA-PA) based on black phosphorus (BP) and amorphous calcium carbonate (ACC). This platform enables precise targeted therapy for diseased bone tissue while improving drug bioavailability. Upon reaching the target site, BA@PDA-PA can respond to the acidic microenvironment of OP lesions, and then release BP and calcium ions (Ca

Indexed as

CalciumNanoparticlesOsteoporosisPhosphorusSea CucumbersAnimalsBone and BonesCalcium CarbonateCell DifferentiationMiceOsteoblastsOsteoclastsOsteogenesisRAW 264.7 CellsReactive Oxygen SpeciesCalciumCalcium CarbonatePhosphorusReactive Oxygen SpeciesAmorphous calcium carbonateAnti-inflammationBlack phosphorusBone-targetingOsteoporosisPH responsiveness

Identifiers

PMID42045957
PMCPMC13270627

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.