ArticleJournal of perinatology : official journal of the California Perinatal Association2026
Bilirubin rate of rise during routine 6-h transcutaneous bilirubin surveillance.
Article in Journal of perinatology : official journal of the California Perinatal Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
objectiveTo evaluate the impact of routine 6-h transcutaneous bilirubin (TcB) surveillance on bilirubin rate-of-rise (ROR) values meeting American Academy of Pediatrics (AAP) age-specific cut-points. STUDY
designRetrospective cohort study of healthy newborns ( ≥ 35 weeks' gestation, ≥2.0 kg) undergoing routine 6-h TcB monitoring during birth hospitalization. ROR was calculated from consecutive TcB pairs and assessed as a screening test for selected hemolytic hyperbilirubinemia neurotoxicity risk factors (HNRFs).
resultsAmong 621 newborns (3787 TcB measurements), 71.8% had ≥1 AAP ROR cut-point. Nearly one-quarter of these events were preceded by a negative slope, indicating frequently variable TcB trajectories. Extending surveillance from 6 to 12 h reduced the odds of AAP ROR cut-points by ~60%. As a screening test for HNRFs, AAP ROR cut-points demonstrated moderate sensitivity (73%) but low specificity (28%).
conclusionsRoutine 6-h TcB surveillance yields frequent AAP ROR cut-points with poor HNRF specificity, limiting short-interval ROR clinical utility.
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