Evidence map›Paper›PMID 42045664›Full record

ArticleNaunyn-Schmiedeberg's archives of pharmacology2026

Discovery of lactylation-associated candidate hub genes and potential curcumin targets in intervertebral disc degeneration.

Weiye Cai, Yingjin Luo, Jiangping Wang, Jian Kong, Yujiang Liu, Binjie Lu, Boen Song, Yue Lu, Bo Xu, Xiaofeng Shen

Abstract read
PubMed Publisher
In one paragraph

Article in Naunyn-Schmiedeberg's archives of pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Weiye Cai *Department of Orthopedics and Traumatology, Suzhou TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Suzhou, Jiangsu Province, China.
Yingjin Luo *Department of Orthopedics and Traumatology (Trauma and Bone-Setting), The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Sichuan Province, Luzhou, China.
Jiangping WangDepartment of Orthopedics and Traumatology, Suzhou TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Suzhou, Jiangsu Province, China.
Jian KongDepartment of Orthopedics and Traumatology, Suzhou TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Suzhou, Jiangsu Province, China.
Yujiang LiuDepartment of Orthopedics and Traumatology, Suzhou TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Suzhou, Jiangsu Province, China.
Binjie LuDepartment of Orthopedics and Traumatology, Suzhou TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Suzhou, Jiangsu Province, China.
Boen SongDepartment of Orthopedics and Traumatology, Suzhou TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Suzhou, Jiangsu Province, China.
Yue LuDepartment of Orthopedics and Traumatology, Suzhou TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Suzhou, Jiangsu Province, China.
Bo XuDepartment of Orthopedics and Traumatology, Suzhou TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Suzhou, Jiangsu Province, China. xubo12080@163.com.
Xiaofeng ShenDepartment of Orthopedics and Traumatology, Suzhou TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Suzhou, Jiangsu Province, China. 29240818@qq.com.

Funding

Key Project of Science and Technology Development of Suzhou Science and Technology Bureau (2025) SYWD2025004Science and Technology Development Project of Suzhou Health Commission SYWD2024036Special Project for Clinical Diagnosis and Treatment Technology of Key Diseases in Suzhou LCZX202320
6 · The paper itself

Abstract

Lactylation, a newly identified post-translational modification of lactate metabolism, has been implicated in degenerative diseases. However, its roles in intervertebral disc degeneration (IVDD) remain unexplored. This study aimed to identify database- and literature-derived lactylation-associated candidate hub genes (abbreviated as "lactylation-associated candidate hub genes") in IVDD, characterize their biological functions, and validate potential targeted therapeutic compounds. Differential expression analysis of the GSE56081 dataset identified 3305 differentially expressed genes (DEGs). Weighted gene co-expression network analysis (WGCNA) screened IVDD-associated key module genes, which were intersected with 327 known lactylation-associated candidate hub proteins to obtain 42 overlapping genes. Protein-protein interaction (PPI) network analysis (STRING/Cytoscape) identified hub genes, followed by GO/KEGG enrichment, immune infiltration (CIBERSORT), molecular docking, and in vitro validation (CCK-8, LDH, RT-qPCR). Five core lactylation-associated candidate hub genes (RBM39, HNRNPU, SFPQ, HNRNPL, DDX5) may potentially regulate IVDD progression through involvement in RNA metabolism, ferroptosis, HIF-1 signaling, and immune microenvironment remodeling (increased CD8

Indexed as

CurcuminIntervertebral Disc DegenerationAnimalsGene Regulatory NetworksHumansMolecular Docking SimulationProtein Interaction MapsCurcuminBioinformatics analysisCurcuminHub genesIntervertebral disc degenerationLactylation

Identifiers

PMID42045664

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.