Evidence map›Paper›PMID 42045572›Full record

ArticleScientific reports2026

Plasma concentration of dexmedetomidine combined with fixed remifentanil for nociceptive and hemodynamic control during skull pin fixation.

Wei-Cheng Tseng, Ann-Shung Lieu, Yu-Chi Tu, Yu-Feng Su, Tsai-Shan Wu, Yi-Wei Kuo, Zhi-Fu Wu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Wei-Cheng TsengDepartment of Anesthesiology, Tri-Service General Hospital, National Defense Medical University, Taipei, 114, Taiwan.
Ann-Shung LieuDepartment of Surgery, Division of Neurosurgery, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, 807, Taiwan.
Yu-Chi TuDepartment of Anesthesiology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, No. 100, Tzyou 1st Road, Sanmin District, Kaohsiung, 807, Taiwan.
Yu-Feng SuDepartment of Surgery, Division of Neurosurgery, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, 807, Taiwan.
Tsai-Shan WuDepartment of Anesthesiology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, No. 100, Tzyou 1st Road, Sanmin District, Kaohsiung, 807, Taiwan.
Yi-Wei KuoDepartment of Anesthesiology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, No. 100, Tzyou 1st Road, Sanmin District, Kaohsiung, 807, Taiwan.
Zhi-Fu WuDepartment of Anesthesiology, Tri-Service General Hospital, National Defense Medical University, Taipei, 114, Taiwan. aneswu@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Skull pin fixation during neurosurgery induces intense nociceptive and hemodynamic responses. Dexmedetomidine is commonly used in anesthesia to enhance perioperative stability; however, its optimal plasma concentration (Cp) when combined with remifentanil at a fixed effect-site concentration (Ce) remains undefined. This prospective study enrolled 24 patients undergoing intracranial surgery to determine the 95% effective concentration (EC

Indexed as

Analgesics, Non-NarcoticBone NailsDexmedetomidineHemodynamicsNociceptionRemifentanilSkullAgedAnalgesics, OpioidFemaleHumansMaleMiddle AgedNeurosurgeryProspective StudiesAnalgesics, Non-NarcoticAnalgesics, OpioidDexmedetomidineRemifentanilAnalgesia nociception indexDexmedetomidineRemifentanilSkull pin fixationTarget-controlled infusionTotal intravenous anesthesia

Identifiers

PMID42045572
PMCPMC13287627

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.