Evidence map›Paper›PMID 42045545›Full record

ArticleScientific reports2026

Antifungal conjugates incorporating N

Joanna Stefaniak-Skorupa, Natalia Maciejewska, Hira Zahoor Rajput, Andrzej S Skwarecki, Piotr Szweda, Sławomir Milewski, Maria J Milewska

Abstract read
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In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Joanna Stefaniak-SkorupaDepartment of Organic Chemistry, Faculty of Chemistry, Gdańsk University of Technology, 11/12 Narutowicza Str, Gdańsk, 80-233, Poland.
Natalia MaciejewskaDepartment of Pharmaceutical Technology and Biochemistry, Faculty of Chemistry and BioTechMed Center, Gdańsk University of Technology, 11/12 Narutowicza Str, Gdańsk, 80-233, Poland.
Hira Zahoor RajputDepartment of Pharmaceutical Technology and Biochemistry, Faculty of Chemistry and BioTechMed Center, Gdańsk University of Technology, 11/12 Narutowicza Str, Gdańsk, 80-233, Poland.
Andrzej S SkwareckiDepartment of Pharmaceutical Technology and Biochemistry, Faculty of Chemistry and BioTechMed Center, Gdańsk University of Technology, 11/12 Narutowicza Str, Gdańsk, 80-233, Poland. andrzej.skwarecki1@pg.edu.pl.
Piotr SzwedaDepartment of Pharmaceutical Technology and Biochemistry, Faculty of Chemistry and BioTechMed Center, Gdańsk University of Technology, 11/12 Narutowicza Str, Gdańsk, 80-233, Poland.
Sławomir MilewskiDepartment of Pharmaceutical Technology and Biochemistry, Faculty of Chemistry and BioTechMed Center, Gdańsk University of Technology, 11/12 Narutowicza Str, Gdańsk, 80-233, Poland. slamilew@pg.edu.pl.
Maria J MilewskaDepartment of Organic Chemistry, Faculty of Chemistry, Gdańsk University of Technology, 11/12 Narutowicza Str, Gdańsk, 80-233, Poland.

Funding

Gdańsk University of Technology, ARGENTUM-Excellence Initiative-Research University' program grant number DEC- 9/2021/IDUB/1.3.3
6 · The paper itself

Abstract

A simplified, artificial siderophore, N5-acetyl-N5-hydroxy-L-ornithine (AHO), can be used as a molecular carrier for the construction of the Trojan Horse-type conjugates exhibiting antifungal activity. Rationally designed AHO-incorporating conjugates with 4-cyano-tryptophan were effectively transported and accumulated in human pathogenic yeasts, especially Candida albicans and Candida glabrata (Nakaseomyces glabratus), known to express the Sit1/Arn1 hydroxamate siderophore uptake system. The AHO-containing conjugates with cispentacin (CP) demonstrated antifungal in vitro activity, particularly against C. albicans and C. glabrata. The antifungal effect of AHO: TML: CP congeners, containing esterase-cleavable trimethyl lock (TML) linker, was substantially higher than that of their AHO: CP counterparts. The latter conjugates were poorly cleaved in the cell-free extract of C. albicans cells. The lowest MIC90 values, namely 16–32 µg mL− 1, were found for TML-containing CP conjugates in iron-deprived growth media, i.e. under conditions stimulating expression of the inducible systems of iron acquisition.

Indexed as

Antifungal AgentsOrnithineCandida albicansCandida glabrataMicrobial Sensitivity TestsSiderophoresAntifungal AgentsOrnithineSiderophoresAntifungal conjugatesHydroxamate siderophoreTrimethyl lockTrojan Horse strategy

Identifiers

PMID42045545
PMCPMC13287593

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.