Evidence map›Paper›PMID 42045540›Full record

ArticleBritish journal of cancer2026

Multiplexed single-cell and spatial profiling reveal B cells and tertiary lymphoid structures as prognostic indicators in pleural mesothelioma.

Angelica Rigutto, Nicolás G Núñez, Jenny C Kienzler, Isabelle Opitz, Mayura Meerang, Martina Haberecker, Nadine Fournier, Joao Lourenço, Raphael Gottardo, Karina Silina and 3 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in British journal of cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Angelica RiguttoDepartment of Medical Oncology and Hematology, University Hospital Zurich, Zurich, Switzerland.
Nicolás G NúñezInstitute of Experimental Immunology, University of Zurich, Zurich, Switzerland.
Jenny C KienzlerInstitute of Experimental Immunology, University of Zurich, Zurich, Switzerland.
Isabelle OpitzDepartment of Thoracic Surgery, University Hospital Zurich, Zurich, Switzerland.ORCID http://orcid.org/0000-0001-5900-9040
Mayura MeerangDepartment of Thoracic Surgery, University Hospital Zurich, Zurich, Switzerland.
Martina HabereckerDepartment of Pathology and Molecular Pathology, University Hospital Zurich, Zurich, Switzerland.ORCID http://orcid.org/0000-0001-5704-7721
Nadine FournierTranslational Data Science Facility, Swiss Institute of Bioinformatics, Agora Cancer Research Center, Lausanne, Switzerland.
Joao LourençoTranslational Data Science Facility, Swiss Institute of Bioinformatics, Agora Cancer Research Center, Lausanne, Switzerland.
Raphael GottardoTranslational Data Science Facility, Swiss Institute of Bioinformatics, Agora Cancer Research Center, Lausanne, Switzerland.ORCID http://orcid.org/0000-0002-3867-0232
Karina SilinaInstitute of Pharmaceutical Sciences, Department of Chemistry and Applied Biosciences, ETH Zurich, Zurich, Switzerland.
Anurag GuptaFaculty of Science and Medicine, University of Fribourg, Fribourg, Switzerland.
Burkhard BecherInstitute of Experimental Immunology, University of Zurich, Zurich, Switzerland.
Alessandra Curioni-FontecedroDepartment of Medical Oncology and Hematology, University Hospital Zurich, Zurich, Switzerland. alessandra.curioni-fontecedro@h-fr.ch.ORCID http://orcid.org/0000-0002-5778-5270

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPleural mesothelioma (PM) is an orphan disease with poor prognosis. While T cell dynamics in the tumor microenvironment (TME) have been extensively studied, the role of B cells remains poorly characterized. Tumor-infiltrating B cells, particularly when organized into tertiary lymphoid structures (TLS), have been associated with improved outcomes of patients with cancer.

methodsIn this study, high-dimensional flow cytometry (HDCyto) and high-plex imaging were applied to analyze fresh-frozen and formalin-fixed paraffin-embedded (FFPE) PM tumor samples, enabling a comprehensive immune profiling of the TME.

resultsWe identified 15 distinct immune cell subsets and stratified tumors into three subgroups with significantly different survival outcomes. Longer survival correlated with increased T and B cell infiltration, with B cells and CD4+ T cells forming TLS in specific cases.

conclusionsThese findings underscore the heterogeneity of PM tumors and highlight the critical role of B cells and TLS in shaping anti-tumor immunity and influencing patient prognosis.

Indexed as

B-LymphocytesMesotheliomaPleural NeoplasmsTertiary Lymphoid StructuresFemaleFlow CytometryHumansLymphocytes, Tumor-InfiltratingMaleMiddle AgedPrognosisSingle-Cell AnalysisTumor Microenvironment

Identifiers

PMID42045540
PMCPMC13310852

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