Evidence map›Paper›PMID 42045539›Full record

ArticleBritish journal of cancer2026

Air pollution and the risk of second primary lung cancer among lung cancer survivors: the prospective UK Biobank cohort study.

Eunji Choi, Sophia Luo, Victoria Y Ding, Anna Graber-Nadich, Julie T Wu, Rita Popat, Iona Cheng, Joel W Neal, Heather A Wakelee, Summer S Han

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in British journal of cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Eunji Choi *Department of Population Health Sciences, Weill Cornell Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0003-1315-1433
Sophia Luo *Department of Epidemiology and Population Health, Stanford University School of Medicine, Stanford, CA, USA.
Victoria Y DingQuantitative Sciences Units, Stanford University School of Medicine, Stanford, CA, USA.
Anna Graber-NadichQuantitative Sciences Units, Stanford University School of Medicine, Stanford, CA, USA.
Julie T WuVeterans Affairs Palo Alto Health Care System, Palo Alto, CA, USA.
Rita PopatDepartment of Epidemiology and Population Health, Stanford University School of Medicine, Stanford, CA, USA.
Iona ChengDepartment of Epidemiology and Biostatistics, University of California, San Francisco, CA, USA.
Joel W NealDivision of Oncology, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0003-3119-9334
Heather A WakeleeDivision of Oncology, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0003-1136-980X
Summer S HanQuantitative Sciences Units, Stanford University School of Medicine, Stanford, CA, USA. summer.han@stanford.edu.ORCID http://orcid.org/0000-0002-2013-6883

Funding

Evaluation of genetic, clinical, and environmental risk factors to establish effective screening strategies for second primary lung cancerR37CA226081 · NCI · STANFORD UNIVERSITY · PI HAN, SUMMER S · 2018 to 2024
$4.3M
Integrating Multiple Electronic Health Records Systems to Improve Lung Cancer OutcomesR01CA282793 · NCI · STANFORD UNIVERSITY · PI Summer S Han · 2023 to 2026
$2.6M
HSRD VA IK2 HX003949NCI NIH HHS R01 CA282793NCI NIH HHS R37 CA226081U.S. Department of Health & Human Services | National Institutes of Health (NIH) R01CA282793
6 · The paper itself

Abstract

backgroundLung cancer survivors have a high risk of second primary lung cancer (SPLC). While air pollution is associated with the risk of initial primary lung cancer (IPLC), especially in never smokers, its effect on SPLC risk is unknown.

methodsWe identified 2439 IPLC patients from the UK Biobank, followed through 2017, linking baseline addresses to 2005-2007 annual average exposures of particulate matter (PM10) and nitrogen dioxide (NO

resultsOf 2439 IPLC patients, 92 (3.7%) developed SPLC over 6561 person-years. The 10-year cumulative incidence of SPLC was 3.98% (3.11-4.85%). A dose-response relationship was observed between PM10 and SPLC risk, with an adjusted hazard ratio (aHR) of 6.43 (2.38-17.32) in the highest vs. lowest (aHR = 1.69 [0.68-4.19]) quintile; a co-pollutant NO

interpretationExposure to PM10 may increase SPLC risk in lung cancer survivors, highlighting the potential value of incorporating environmental factors into SPLC surveillance to identify high-risk individuals.

Indexed as

Air PollutionLung NeoplasmsNeoplasms, Second PrimaryAgedBiological Specimen BanksEnvironmental ExposureFemaleHumansIncidenceMaleMiddle AgedNitrogen DioxideParticulate MatterProspective StudiesRisk FactorsSmokingNitrogen DioxideParticulate Matter

Identifiers

PMID42045539
PMCPMC13186603

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.