ArticleCommunications medicine2026
Incorporation of the National Institute of Health (NIH) sex as a biological variable policy by R01 grant awardees.
Article in Communications medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Claims of sex-dependent effects in the behavioral and brain sciences are infrequently supported by valid statistical comparisons.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Incorporation of the National Institute of Health (NIH) sex as a biological variable policy by R01 grant awardees.Communications medicine · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe National Institutes of Health (NIH) Sex as a Biological Variable (SABV) policy aims to improve the rigor and reproducibility of biomedical research by encouraging sex-inclusive study designs and sex-based analyses.
methodsTo evaluate policy implementation, we examine 574 funded publications (2017-2024) linked to grants from 21 NIH Institutes and Centers. We assess sex inclusion and sex-based reporting and analyses, while examining associations with author gender.
resultsSixty-one percent of studies include both sexes, with human-subject research more likely to do so than non-human studies (p = 1.31×10
conclusionsThese findings suggest that while the SABV policy has encouraged sex inclusion, gaps remain in sex-based analyses. Author gender may influence these research practices, underscoring the need for continued efforts to fully integrate SABV into NIH-funded research studies.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.