Effect of Valved Versus Non-valved Conduits on Ventricular Size and Function in Stage I Palliation for Hypoplastic Left Heart Syndrome.

Alexandra Linder, Halil Beqaj, Nimrod Goldshtrom, Amee Shah, Andrew Goldstone, David Kalfa, Michael Dilorenzo

Abstract read

In one paragraph

Article in Pediatric cardiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Alexandra LinderDivision of Pediatric Cardiology, Department of Pediatrics, Columbia University Vagelos College of Physicians and Surgeons and New York- Presbyterian Morgan Stanley Children's Hospital, New York, NY, USA. alinder3@nymc.edu.ORCID http://orcid.org/0000-0002-5426-5157

Halil BeqajSection of Pediatric and Congenital Cardiac Surgery, Division of Cardiac, Thoracic, and Vascular Surgery, Department of Surgery, Columbia University Vagelos College of Physicians and Surgeons and New York- Presbyterian Morgan Stanley Children's Hospital, New York, NY, USA.

Nimrod GoldshtromDivision of Neonatology, Department of Pediatrics, Columbia University Vagelos College of Physicians and Surgeons and New York-Presbyterian Morgan Stanley Children's Hospital, New York, NY, USA.

Amee ShahDivision of Pediatric Cardiology, Department of Pediatrics, Columbia University Vagelos College of Physicians and Surgeons and New York- Presbyterian Morgan Stanley Children's Hospital, New York, NY, USA.

Andrew GoldstoneSection of Pediatric and Congenital Cardiac Surgery, Division of Cardiac, Thoracic, and Vascular Surgery, Department of Surgery, Columbia University Vagelos College of Physicians and Surgeons and New York- Presbyterian Morgan Stanley Children's Hospital, New York, NY, USA.

David KalfaSection of Pediatric and Congenital Cardiac Surgery, Division of Cardiac, Thoracic, and Vascular Surgery, Department of Surgery, Columbia University Vagelos College of Physicians and Surgeons and New York- Presbyterian Morgan Stanley Children's Hospital, New York, NY, USA.

Michael DilorenzoDivision of Pediatric Cardiology, Department of Pediatrics, Columbia University Vagelos College of Physicians and Surgeons and New York- Presbyterian Morgan Stanley Children's Hospital, New York, NY, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Interstage mortality remains high after introduction of right ventricle (RV) to pulmonary artery conduits to stage I palliation for hypoplastic left heart syndrome (HLHS). Prior studies have not shown long-term survival benefit with conduits, likely due to multiple factors including regurgitation contributing to decreased RV function. Valved conduits (VC) were introduced to address these limitations. The study aimed to assess differences in RV size and function using echocardiography during the interstage period between patients undergoing stage I palliation with VC versus non-valved conduits (NVC). We hypothesized patients with VC would have smaller increases in RV size and improved function. Twenty-five neonates with HLHS who underwent Stage I palliation with VC were compared to 25 neonates with NVC from 2013 to 2022. Primary outcomes were RV end-diastolic area (EDA) and function measured by fractional area change and global longitudinal strain. There was no difference in EDA increase one month post-operatively between groups, but the VC group had a smaller increase in EDA pre-stage II compared to the NVC group (3.23 v 4.38 cm2, p = 0.01). Function was not significantly different pre-stage II: GLS in VC -16.0% v NVC − 18.7% (p = 0.39) and FAC in VC 41% v NVC 38% (p = 0.26). There was no difference in interstage cardiac events or mortality between VC and NVC groups. Patients with VC at Stage I palliation had smaller interstage increases in ventricular size compared to NVC, but no differences in functional parameters or outcomes. Larger, longitudinal studies are needed to further examine the hemodynamic benefits of VC in the interstage period and beyond.

Indexed as

Fractional area changeHypoplastic left heart syndromeRight ventricle global longitudinal strainRight ventricle to pulmonary artery conduitSingle ventricle palliation

Identifiers

PMID42045500

DOI10.1016/j.cjcpc.2022.05.002

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