SynthesisEye (London, England)2026
Low-concentration atropine for management of myopia progression: does iris colour matter?
Synthesis in Eye (London, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- [Topical atropine for myopia prevention : Current study situation].Die Ophthalmologie · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
backgroundTo investigate interactions between iris colour and low-concentration atropine on outcomes relevant to clinical myopia management
methodsA post-hoc, exploratory meta-analysis of three randomised clinical trials investigating atropine 0.01% or 0.05% eye drops vs placebo: the Western Australian Atropine Treatment of Myopia study, the Myopia Treatment Study and the Myopia Outcome Study of Atropine in Children. Iris colour was graded as brown or not brown (including blue/green/hazel). Change in accommodative amplitude, pupil diameter, spherical equivalent refraction (SER) and axial length were assessed using linear mixed models.
resultsIn participants (baseline ages 5-16 years) using atropine 0.01% (n = 396), pupil diameter change did not differ by iris colour (p ≥ 0.15), while accommodative amplitude decreased more in not brown vs brown iris colour groups at month 12 (adjusted difference = -1.07D, 95% CI: -2.02, -0.12, p = 0.03), but not at month 24 (p = 0.76). Change in pupil and accommodative outcomes with 0.05% atropine (n = 66) did not differ by iris colour (p ≥ 0.10). Among not brown iris colour participants, myopia progression was lower in the atropine 0.01% vs placebo group at 24 months (SER: +0.17D, 95% CI: 0.07, 0.26, p < 0.001; axial length: -0.09 mm, 95% CI: -0.12, -0.05, p < 0.001), but not among brown iris colour participants (SER: -0.08D, 95% CI: -0.20, 0.05; axial length: +0.03 mm, 95% CI: -0.02, 0.07).
conclusionChange in pupil diameter and accommodative amplitude with low-concentration atropine largely did not differ between iris colour groups. Among participants using 0.01% atropine eye drops, there was less 24-month myopia progression compared to placebo in participants with blue/green irides, but not with brown irides.
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Registered trials
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