Evidence map›Paper›PMID 42045332›Full record

ArticleScientific reports2026

Structural and transcriptomic alterations underlying the progression of aortic dissection in Fbn1

Md Al Amin Sheikh, Kenichi Kimura, Eri Motoyama, Keiichi Asano, Violette Deleeuw, Patrick Sips, Chiho Tokunaga, Hiroko Matsunaga, Sachiko Kanki, Shigeki Koizumi and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Md Al Amin SheikhLife Science Center for Survival Dynamics, Tsukuba Advanced Research Alliance (TARA), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8577, Japan.
Kenichi KimuraLife Science Center for Survival Dynamics, Tsukuba Advanced Research Alliance (TARA), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8577, Japan. kkimura@tara.tsukuba.ac.jp.
Eri MotoyamaLife Science Center for Survival Dynamics, Tsukuba Advanced Research Alliance (TARA), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8577, Japan.
Keiichi AsanoLife Science Center for Survival Dynamics, Tsukuba Advanced Research Alliance (TARA), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8577, Japan.
Violette DeleeuwDepartment of Biomolecular Medicine, Ghent University, Ghent, Belgium.
Patrick SipsDepartment of Biomolecular Medicine, Ghent University, Ghent, Belgium.
Chiho TokunagaDepartment of Cardiovascular Surgery, University of Tsukuba, Tsukuba, Japan.
Hiroko MatsunagaResearch Organization for Nano and Life Innovation, Waseda University, Tokyo, Japan.
Sachiko KankiThoracic and Cardiovascular Surgery, Osaka Medical and Pharmaceutical University, Osaka, Japan.
Shigeki KoizumiLife Science Center for Survival Dynamics, Tsukuba Advanced Research Alliance (TARA), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8577, Japan.
Kaori SugiyamaLife Science Center for Survival Dynamics, Tsukuba Advanced Research Alliance (TARA), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8577, Japan.
Julie De BackerDepartment of Cardiology, Center for Medical Genetics, Ghent University Hospital, Ghent, Belgium.
Lynn Y SakaiDepartment of Molecular & Medical Genetics, Department of Surgery, Oregon Health and Science University, Oregon, USA.
Haruko TakeyamaResearch Organization for Nano and Life Innovation, Waseda University, Tokyo, Japan.
Yuji HiramatsuDepartment of Cardiovascular Surgery, University of Tsukuba, Tsukuba, Japan.
Haruka OzakiLaboratory for AI Biology, RIKEN Center for Biosystems Dynamics Research, Kobe, Japan.
Hiromi YanagisawaLife Science Center for Survival Dynamics, Tsukuba Advanced Research Alliance (TARA), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8577, Japan. hkyanagisawa@tara.tsukuba.ac.jp.

Funding

Japan Agency for Medical Research and Development JP23ek0109553Japan Agency for Medical Research and Development, Research Support Project for Life Science and Drug Discovery (BINDS) JP25am121055Japan Society for the Promotion of Science Grant-in-Aid for Special Purposes Grant Number 23KJ0282Japan Society for the Promotion of Science Grant-in-Aid for Special Purposes Grant Number 25KJ1717Japan Society for the Promotion of Science KAKENHI Grant Number JP23H00431Japan Society for the Promotion of Science KAKENHI Grant Number JP23K08247Japan Society for the Promotion of Science KAKENHI Grant Number JP25K0450Marfan Foundation The Everest Grant
6 · The paper itself

Abstract

Aortic dissection (AD) is characterized by separation within the medial layers of the aortic wall. Pathogenic variants in the fibrillin-1 gene (FBN1), which cause Marfan syndrome, represent a major genetic cause of AD. In a recently established Fbn1

Indexed as

Aortic DissectionFibrillin-1TranscriptomeAdipokinesAnimalsAortaDisease Models, AnimalDisease ProgressionHumansMaleMarfan SyndromeMiceAdipokinesFbn1 protein, mouseFibrillin-1

Identifiers

PMID42045332
PMCPMC13287636

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.