Propofol upregulates ANGPTL4 gene and protein expression to inhibit biological behavior of colon cancer cells.

Jia Yang, Jie Gao, Lu Yang, Fuyu Li, Liqun Mo, Yiping Bai

Abstract read

In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jia Yang *Department of Anesthesiology, The Affiliated Hospital, Southwest Medical University, 25 Taiping street, Luzhou, 646000, China.

Jie Gao *Department of Anesthesiology, The Affiliated Hospital, Southwest Medical University, 25 Taiping street, Luzhou, 646000, China.

Lu YangDepartment of Anesthesiology, The Affiliated Hospital, Southwest Medical University, 25 Taiping street, Luzhou, 646000, China.

Fuyu LiDepartment of Anesthesiology, The Affiliated Hospital, Southwest Medical University, 25 Taiping street, Luzhou, 646000, China.

Liqun MoDepartment of Anesthesiology, The Affiliated Hospital, Southwest Medical University, 25 Taiping street, Luzhou, 646000, China. 34701107@qq.com.

Yiping BaiDepartment of Anesthesiology, The Affiliated Hospital, Southwest Medical University, 25 Taiping street, Luzhou, 646000, China. baiyiping0608@163.com.

Funding

Luzhou City Science and Technology Plan Project 2023JYJ043Scientific Research Project of Southwest Medical University 20220N100The study was supported by the Medical Science and Technology Project of Sichuan Provincial Health Commission 21PJ094

6 · The paper itself

Abstract

Propofol, a clinically prevalent intravenous anesthetic, has garnered significant research interest in recent years due to its potential antitumor properties. This study examines whether propofol influences colon cancer cell behavior through modulation of ANGPTL4. In a murine intraperitoneal colon cancer model, propofol administration significantly suppressed tumor growth and reduced tumor mass. In vitro experiments demonstrated dose-dependent inhibition of colon cancer cell proliferation, migration, and invasion following propofol treatment. RNA sequencing revealed substantial upregulation of ANGPTL4 gene expression, while Western blot confirmed parallel upregulation of ANGPTL4 protein expression. Crucially, ANGPTL4 knockdown markedly attenuated propofol’s antitumor effects, indicating ANGPTL4-dependent mechanisms. Our results show that propofol suppresses colon cancer cell proliferation, migration, and invasion through upregulation of both ANGPTL4 gene and protein expression, thereby identifying a novel potential therapeutic target for colon cancer treatment.

Indexed as

Angiopoietin-Like Protein 4Colonic NeoplasmsGene Expression Regulation, NeoplasticPropofolUp-RegulationAnimalsCell Line, TumorCell MovementCell ProliferationHumansMaleMiceAngiopoietin-Like Protein 4ANGPTL4 protein, humanPropofolANGPTL4Colon cancerPropofolRegulation of cell behaviorTumor suppression

Identifiers

PMID42045301

DOI10.1038/s41598-026-50245-3

PMCPMC13284188

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LicenceCC BY-NC-ND

Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.